Control of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation

By E. Eide, Margaret F. Woolf, Heeseog Kang, P. Woolf, W. Hurst, F. Camacho, E. Vielhaber, A. Giovanni, D. Virshup. Molecular and Cellular Biology, 2005

446 citations recorded by the source corpus.

Subfields: Aging, Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/66a0af36fd60f796a1e22fc4c2663645363f47be

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. J. Takahashi
2. F. Alt
3. C. Dibner
4. A. Jetten
5. U. Schibler
6. R. Mostoslavsky

In Endocrine and Autonomic Systems

1. J. Takahashi
2. C. H. Ko
3. C. Dibner
4. A. Jetten
5. U. Schibler
6. Heekyung Hong
7. Erin L. McDearmon
8. U. Albrecht

In Plant Science

1. J. Takahashi
2. C. H. Ko
3. A. Jetten
4. U. Schibler
5. C. Dibner

Citations in the corpus

• SIRT1 regulates circadian clock gene expression through PER2 deacetylation. (2008, background): “CKI has been reported to phosphorylate PER2 protein, thereby regulating PER2 protein stability (Eide et al., 2005).”
• Molecular components of the mammalian circadian clock. (2006, background): “Another casein kinase, CK1δ, was later found to phosphorylate the PER proteins and that this CK1ε/δ-mediated phosphorylation targets the PER proteins for ubiquitination by βTrCP and degradation by the 26S proteasome (Camacho et al. 2001; Eide et al. 2005; Shirogane et al. 2005; Vanselow et al. 2006)”
• Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “…casein kinases and other kinases and acetylation, play a critical role in regulating protein-protein interactions, the nuclear localization, transcriptional activity, and turnover of clock proteins [Eide et al., 2005; Gallego and Virshup, 2007; Ko and Takahashi, 2006; Ripperger and Schibler, 2001].”
• The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “In vitro studies have suggested that the β-TrCP1 and FBXL3 E3 ubiquitin ligase complexes directly target the PER and CRY proteins, respectively, for degradatio”