SIRT1 regulates circadian clock gene expression through PER2 deacetylation.

By Gad Asher, D. Gatfield, Markus Stratmann, H. Reinke, C. Dibner, F. Kreppel, R. Mostoslavsky, F. Alt, U. Schibler. Cell, 2008

1,367 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/44fef552a680adf4403e3709b850dfebd1a39d25

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. J. Takahashi
2. U. Albrecht
3. A. Jetten
4. C. Green
5. L. Galluzzi
6. D. Sinclair
7. Guido Kroemer
8. Johan Auwerx

In Endocrine and Autonomic Systems

1. J. Takahashi
2. U. Albrecht
3. C. Green
4. C. H. Ko
5. Ethan D. Buhr
6. J. Mohawk
7. C. Dibner
8. A. Jetten

In Plant Science

1. J. Takahashi
2. U. Albrecht
3. C. H. Ko
4. Ethan D. Buhr
5. A. Jetten
6. C. Green
7. U. Schibler
8. C. Dibner

Citations in the corpus

• Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “It has been become increasingly clear that SIRT1 functions as a link between the circadian rhythm circuitry, cellular metabolism, and nuclear receptors, including RORs [Asher et al., 2008; Nakahata et al., 2008; Schwer and Verdin, 2008].”
• NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (2015, background): “Further evidence indicates that SIRT1 is key to linking nutrients to circadian rhythm (Asher et al., 2008; Chang and Guarente, 2013; Nakahata et al., 2008).”
• Therapeutic potential of NAD-boosting molecules: the in vivo evidence (2018, neutral): “The levels of NAMPT expression are believed to control the body’s response to stress, exercise, nutrient status (FrydelundLarsen et al., 2007; Rappou et al., 2016; Yang et al., 2007), and circadian rhythms (Asher et al., 2008; Masri et al., 2014; Ramsey et al., 2009).”
• SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “Indeed, although most findings on the role of SIRT1-CLOCK were derived from studies in mammalian cells, most have also been confirmed in peripheral tissues such as liver (17, 227).”
• Molecular components of the Mammalian circadian clock. (2013, background): “Intriguingly, the rhythmic deacetylation of histone H3 at the promoters of circadian genes is regulated by the deacetylase SIRT1, which is sensitive to NAD levels (Nakahata et al. 2008; Asher et al. 2008).”
• Timing to perfection: the biology of central and peripheral circadian clocks. (2012, background): “Metabolic output is indicated by the PER2/PPAR and CRY/glucocorticoid receptor (GR) complexes (Purple arrows).”
• Metabolic Control of Longevity. (2016, background): “SIRT1 contributes to the regulation of circadian rhythms by a transcriptional mechanism impinging on the deacetylation of histone H3, aryl hydrocarbon receptor nuclear translocator-like (Arntl, also known as Bmal1), and period circadian clock 2 (Per2) (Asher et al., 2008).”
• The mammalian circadian timing system: organization and coordination of central and peripheral clocks. (2010, background): “Therefore, some cells appear to be more sensitive to the absence of PER1 than do other cells, perhaps because PER2 production is upregulated in these cells.”
• NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential (2020, background): “Besides, the oscillation activation of SIRT1 also regulates the circadian dynamics via deacetylation of the core clock repressor PER2 and mixed-lineage leukemia 1 (MLL1), thereby controlling rhythmic chromatin property and the activity of BMAL1: CLOCK complex.(36,38,238,242,244) Similar to sirtuins,”
• RNA-methylation-dependent RNA processing controls the speed of the circadian clock. (2013, neutral): “Metabolism in turn can adjust the clock, for example by modulating acetylation/deacetylation of histones on promoters activated by core clock protein complex CLOCK:ARNTL (Nakahata et al., 2008) or directly by affecting acetylation status of PER proteins (Asher et al., 2008).”
• SIRT1 and other sirtuins in Metabolism (2013, background): “Finally, SIRT1 plays an important role in maintaining circadian regulation of metabolic processes in the liver by regulating the cell-autonomous, circadian clock in that tissue [69,70].”