Epigenetic mechanisms in memory formation

By Jonathan M. Levenson, J. Sweatt. Nature Reviews Neuroscience, 2005

777 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3bb6007f0a8d7ba86a1f941fe62d1b789936f054

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. M. Le Moal
2. E. Nestler
3. Arvind Kumar
4. G. Koob
5. Nadia M. Tsankova
6. W. Renthal
7. Y. Dudai
8. E. Kandel

In Genetics

1. E. Nestler
2. M. Le Moal
3. G. Koob
4. Y. Dudai
5. E. Kandel
6. C. Alberini
7. Peter W. Kalivas
8. V. Krishnan

In Molecular Biology

1. G. Koob
2. E. Nestler
3. M. Le Moal
4. Y. Dudai
5. C. Alberini
6. W. Renthal
7. Arvind Kumar
8. Nadia M. Tsankova

Citations in the corpus

• The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB (2012, background): “Although, epigenetic mechanisms were widely known to be involved in the formation and long-term storage of cellular information in response to transient environmental signals, the discovery of their putative relevance in adult brain function is relatively recent [68,69].”
• Latent enhancers activated by stimulation in differentiated cells. (2013, neutral): “Indeed, it will be interesting to determine if brain memory circuits, in which epigenetic phenomena have been suggested to play an important role (Levenson and Sweatt, 2005), also involve latent enhancers.”
• Epigenetic regulation in psychiatric disorders (2007, background): “The formation of long-term memories, by analogy to pathophysiological mechanisms of depression and addiction, is thought to entail lasting changes in gene expression, and there is growing evidence that histone modifications and DNA methylation may be involve”
• Addiction and the brain antireward system. (2008, background): “The concept of chromatin remodeling (an important determinant of gene expression) has provided one example of how stable changes in gene expression may be produced in neurons and glia to provoke long-lasting changes in physiology and behavior (Colvis et al. 2005, Levenson & Sweatt 2005).”
• Transcription Factors in Long-Term Memory and Synaptic Plasticity (2009, positive): “Recent work has confirmed that changes in chromatin structure and posttranslational modifications accompany long-term memory formation (79, 138).”
• Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation (2007, background): “Chromatin modification is emerging as a fundamental molecular mechanism for the regulation of transcription involved in neurodevelopmental disorders (such as Rubinstein-Taybi syndrome and Rett syndrome), neurodegenerative diseases, epilepsy, and drug addiction (Steffan et al., 2001; Shahbazian and Z”
• The molecular and systems biology of memory. (2014, neutral): “…to be involved in the formation and long-term storage of cellular information in response to transient environmental stimuli during development, but their possible relevance to adult brain function was discovered only in relatively recent studies (Guan et al., 2002; Levenson and Sweatt, 2005).”
• The restless engram: consolidations never end. (2012, background): “Chromatin Alteration and Epigenetic Changes in Memory Consolidation Epigenetic mechanisms, which change gene expression but do not alter the underlying DNA, werewidely known to be involved in the formation and long-term storage of cellular information in response to transient environmental stimuli d”