The role of the NKG2D immunoreceptor in immune cell activation and natural killing.

By Amanda M. Jamieson, A. Diefenbach, C. Mcmahon, N. Xiong, J. Carlyle, D. Raulet. Immunity, 2002

700 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/99117262b498051c090eae2062d223815b03918e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. I. Waldhauer
2. A. Steinle
3. D. Raulet
4. L. Lanier
5. S. Gasser
6. J. Matsuda
7. W. Deng
8. N. Xiong

Citations in the corpus

• Regulation of ligands for the NKG2D activating receptor (2013, background): “Expression by certain CD4+ T cells has also been reported, at least in humans, although in mice it is difficult to detect expression by conventional CD4+ T cells (12, 13).”
• Up on the tightrope: natural killer cell activation and inhibition (2008, background): “22 ), which is a type II transmembrane-anchored glycoprotein expressed as a disulfide-bonded homodimer on the surface of NK cells, γδ T cells and CD8 + T cell”
• NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. (2008, background): “NKG2D is a stimulatory immunoreceptor expressed by natural killer (NK) cells and various T cell subsets, including activated CD8 T cells, fractions of gamma-delta, NKT cells, and some activated CD4 T cells (Groh et al., 2001; Groh et al., 1999; Jamieson et al., 2002; Raulet, 2003; Saez-Borderias et ”
• Roles of the NKG2D immunoreceptor and its ligands (2003, background): “In mice, NKG2D is expressed on the cell surface of almost all NK cell”
• T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. (2004, background): “These receptors have varied and critical roles in the regulation of NK cell effector 4 Department of Immunology University of Colorado Health Sciences Center, function, and major recent advances have been made in understanding their function (Arase et al., 2002; Faure National Jewish Medical and Res”
• T cell– and B cell–independent adaptive immunity mediated by natural killer cells (2006, background): “Similarly, although NK cell–mediated CHS could be blocked with anti-NKG2D, the fact that this activating receptor is expressed on almost all NK cell”
• The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy (2017, background): “It is also expressed by most NKT cells and activated CD8+ T cells in mice, and all CD8+ T cells and a subset of γδ T cells in humans (25).”
• Dendritic cells prime natural killer cells by trans-presenting interleukin 15. (2007, background): “In contrast to human NK cells (Bryceson et al., 2006), naive NK cells from mice are not appreciably activated by target cells (e.g., YAC-1) known to express ligands for two or more stimulatory immunoreceptors (Jamieson et al., 2002; Pessino et al., 1998).”
• NK cells and cancer immunosurveillance (2008, background): “In mice, NKG2D expression significantly differs from the human situation, since only a fraction of gd T cells and activated or memory CD8þ ab T cells, but not naive CD8þ ab T cells express NKG2D (Ho et al., 2002; Jamieson et al., 2002).”