Dendritic cells prime natural killer cells by trans-presenting interleukin 15.

By M. Lucas, William Schachterle, K. Oberle, P. Aichele, A. Diefenbach. Immunity, 2007

944 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/df2f783ee3ec1445f2f6782c76b9ee3bf8783ca8

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In Immunology

1. M. Peterson
2. Chao Yang
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4. S. Rajagopalan
5. H. Kim
6. Misako Matsumoto
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8. T. Walzer

Citations in the corpus

• TLR3: interferon induction by double-stranded RNA including poly(I:C). (2008, background): “Recently, a critical role of CD11c DCs in NK cell activation has been demonstrated in vivo [83].”
• RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells (2009, background): “Given published data documenting dendritic cell–mediated NK cell primin”
• Natural killer cells in cancer biology and therapy (2020, background): “Similar to other innate immune cells that are unable to accurately recognize target cells, NK cells rely on other stromal cells, including DC, which trans-presents IL-15 for NK cell activation [96], and MICA-expressing monocytes, which bind to Fc receptor to enhance antitumor function [97], to fully”
• Natural Killer Cells: Development, Maturation, and Clinical Utilization (2018, background): “Activated DCs and macrophages generate interleukin (IL)-15, IL-12, IL-18, IL-35, IFN-α, IFN-β, IL-27, IL-1β, and IL-23.”
• Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition (2013, background): “Stimulation of NK cells by type I IFN has interesting properties.”
• TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway (2016, background): “Mechanistically, this phenomenon involves trans-presentation of IL-15 and IL-15 receptor a (IL-15Ra) complexes by myeloid cells, such as dendritic cells, and the cell surface amounts of these complexes are increased during infections (8).”
• Functions of natural killer cells (2008, background): “Like T cells, NK cells thus require 'priming' for full activatio”