Up on the tightrope: natural killer cell activation and inhibition

By L. Lanier. Nature Immunology, 2008

1,677 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/dde27547335d75082d2dee3a2ce21f37ed8d412b

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In Immunology

Citations in the corpus

The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity (2009, background): “All of the inhibitory receptors share a common immune receptor tyrosinebased inhibitory motif (ITIM) in their cytoplasmic regions, which delivers the inhibitory signal (3).”
NK cell development, homeostasis and function: parallels with CD8+ T cells (2011, background): “Inhibitory NK cell receptors contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic tail, and these motifs can recruit SH2 domain-containing protein tyrosine phosphatase 1 (SHP1; also known as PTPN6) and SH2 domain-containing inositol 5-phosphatase (SHIP”
Natural Killer Cells: Development, Maturation, and Clinical Utilization (2018, background): “The varied nature of NKRs and the absence of signaling domains in their cytoplasmic tails necessitates the association and recruitment of receptorassociated adaptor molecules for signal transduction (96).”
Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent anti-tumor activity (2017, positive): “CD3ζ is crucial for both T and NK cell signaling and activation.(30, 31) While CD28 is well recognized as an important costimulatory molecule for T cell activation,(32) its role in NK cell activation is less clear; however, human fetal NK cells and a number of NK cell lines express CD28 and can kill”
Expansion of a unique CD57+NKG2Chi natural killer cell subset during acute human cytomegalovirus infection (2011, background): “NK cells preferentially recognize pathogeninfected cells, tumor cells, and stressed cells that express ligands for the activating NK receptors or cells that have down-regulated MHC class I molecules, which are ligands for NK inhibitory receptors (7).”
CAR-NK cells: A promising cellular immunotherapy for cancer (2020, background): “[4] Activation of NK cell cytotoxic activity is controlled by signals integrated from an array of germline-encoded activating and inhibitory receptors (Fig.”
The polarization of immune cells in the tumour environment by TGFβ (2010, background): “Targeted killing by NK cells requires stimulating the NK cell activating receptors natural killer group 2, member D (NKG2D), NKp46, NKp44 and NKp30 (Ref”
The blockade of immune checkpoints in cancer immunotherapy (2012, background): “Killer inhibitory receptors are a broad category of inhibitory receptors that can be divided into two classes based on structure: killer cell immunoglobulin-like receptors (KIRs) and C-type lectin receptors, which are type II transmembrane receptor”