NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy.

By N. Guerra, Y. Tan, N. Joncker, Augustine Choy, Fermin Gallardo, N. Xiong, S. Knoblaugh, D. Cado, N. Greenberg, D. Raulet. Immunity, 2008

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Targeting natural killer cells and natural killer T cells in cancer (2012, background): “In vivo , NKG2D was shown to be crucial for the immunosurveillance of epithelial and lymphoid malignancies in two transgenic models of de novo tumorigenesi”
Immunity, inflammation, and cancer: an eternal fight between good and evil. (2015, positive): “These NKG2D ligands are upregulated during the DNA damage response and cell cycle progression via E2F transcription factors (89).”
Roles of the immune system in cancer: from tumor initiation to metastatic progression (2018, background): “In line with the important role of NKG2D for immune surveillance, mice deficient in NKG2D receptor are more susceptible to tumor development (Guerra et al. 2008).”