T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells.

By M. Townsend, Amy S. Weinmann, J. Matsuda, R. Salomon, P. Farnham, C. Biron, L. Gapin, Laurie H. Glimcher. Immunity, 2004

807 citations recorded by the source corpus.

Subfields: Immunology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation (2012, background): “T-bet-deficient mature NK cells are thought to possess lytic and cytokine- secreting function (Townsend et al., 2004).”
The transcription factor PLZF (Zbtb16) directs the effector program of the NKT cell lineage (2008, background): “…et al., 2005), Gata-3 (Kim et al., 2006), and T-bet (Matsuda et al., 2006) showed partial defects of NKT cells as well as T cells and NK cells (Egawa et al., 2007; Intlekofer et al., 2005; Lacorazza et al., 2002; Pai et al., 2003; Samson et al., 2003; Taniuchi et al., 2002; Townsend et al., 2004).”
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. (2007, background): “However, as shown here for antigen-specific memory CD8 T cells and as described previously for NKT cells, T-bet acts in a non-redundant manner to sustain CD122 expression (Matsuda et al., 2007; Townsend et al., 2004).”