Roles of the NKG2D immunoreceptor and its ligands

By D. Raulet. Nature reviews. Immunology, 2003

1,461 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7a13c5292fccf34f2bd13caab465b147298185ca

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

NK cells and cancer immunosurveillance (2008, background): “NKG2D: a unique activating receptor of cytotoxic lymphocytes NKG2D is a homodimeric, C-type lectin-like activating receptor expressed by cytotoxic lymphocytes and encoded in the NKC (Bauer et al., 1999; Raulet, 2003).”
Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. (2004, background): “ITAM-bearing DAP12 can induce a full signaling cascade resulting in cytolysis, cytokine Summary secretion, and proliferation (reviewed in Lanier, 2001; Raulet, 2003; Vivier et al., 2002; Yokoyama, 2000), whereas A major function of NKG2D linking innate and adaptive YXXM-bearing DAP10 seems to exert ”
Targeting natural killer cells and natural killer T cells in cancer (2012, background): “In addition to the recognition of microbial molecules by a variety of innate immune receptors, a process known as 'infectious non-self recognition', it has been shown that several receptors of innate immune cells can detect internal changes that occur in damaged host tissues, leading to the concept ”
NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. (2008, background): “NKG2D is a stimulatory immunoreceptor expressed by natural killer (NK) cells and various T cell subsets, including activated CD8 T cells, fractions of gamma-delta, NKT cells, and some activated CD4 T cells (Groh et al., 2001; Groh et al., 1999; Jamieson et al., 2002; Raulet, 2003; Saez-Borderias et ”
The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans (2009, background): “Although multiple ligands for NKG2D and DNAM-1 have been identified (Bottino et al., 2005), tumor cell surface ligands for the NCR family have remained”
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. (2004, background): “…their function (Arase et al., 2002; FaureNational Jewish Medical and Research Center Denver, Colorado 80206 et al., 2003; Jamieson et al., 2002; Nakamura et al., 2000; Ogasawara et al., 2003; Raulet, 2003; Riteau et al., 2003;5 Department of Molecular Microbiology and Immunology Seaman, 2000).”
Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition (2013, background): “These ligands include MICA, MICB, and the family of ULBP molecules in humans and H60, MULT1 and the family of RAE-1 molecules in mice (44).”
Regulation of ligands for the NKG2D activating receptor (2013, background): “Furthermore, some of the ligands are transmembrane proteins, while others are glycosylphosphatidylinositol (GPI)-linked (2, 7, 30) (Figure 1).”