Molecular mechanisms regulating Th1 immune responses.

By S. Szabo, B. Sullivan, S. Peng, Laurie H. Glimcher. Annual Review of Immunology, 2003

1,145 citations recorded by the source corpus.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/97ed24dccd78c52e3aa508786b653745ad1430d8

How researchers see this paper

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In Immunology

1. W. E. Paul
2. Jinfang Zhu
3. C. Dong
4. Jian-Xin Lin
5. W. Liao
6. F. Sallusto
7. W. Leonard
8. A. Lanzavecchia

In Physiology

1. W. Leonard
2. W. Liao
3. Jian-Xin Lin
4. L. Ivashkiv

Citations in the corpus

• Regulation of IFN-γ Production by B Effector 1 Cells: Essential Roles for T-bet and the IFN-γ Receptor1 (2005, background): “Although it has been previously proposed by many groups that an IFN- -driven positive feedback loop must regulate IFN- production by Th1 cells (12), our data are the first to show that this autocrine feedback loop directly regulates IFN- at the transcriptional level.”
• NFAT proteins: key regulators of T-cell development and function (2005, background): “These structural changes can be detected by the appearance of DNase-I-hypersensitivity sites, which identify regions in the chromatin with increased accessibility to DNase and, by implication, to transcription factor”
• Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy (2013, positive): “CD4+ T cells can differentiate into multiple helper T cell populations upon antigen exposure, including Th1, Th2, Th9, Th17, and Tfh cells (Crotty, 2011; Jabeen and Kaplan, 2012; Littman and Rudensky, 2010; Paul and Zhu, 2010; Szabo et al., 2003) (Figure 5).”
• Activation, coactivation, and costimulation of resting human natural killer cells (2006, background): “TNF-a initiates proinflammatory cytokine cascades (4), while IFN-g promotes T-helper 1 cell differentiation (5), enhances major histocompatibility complex (MHC) class I expression (6), and has potent antimycobacterial, anti-viral, and growth inhibitory effects (7, 8).”
• Phenotypic and functional specialization of FOXP3+ regulatory T cells (2011, background): “Production of these polarizing cytokines is dictated by the type of pathogen encountered, such that: TGFβ and IL-6 direct the development of IL-17-producing T H 17 cells during extracellular bacterial or fungal infection; IFNγ and IL-12 drive the differentiation of IFNγ-producing T H 1 cells that he”
• FOLLICULAR HELPER T CELLS: LINEAGE AND LOCATION (2009, background): “Stat1dependent IFN-g signals induce the Th1 master regulator T-bet that not only induces further IFN-g production but also inhibits IL-4 expression (Szabo et al., 2003).”
• T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. (2004, background): “Similarly, T-bet / NK the only known T-box gene selectively expressed in the cells showed increased expression of cKit and V integlymphoid system (Szabo et al., 2003).”
• IL-2 Family Cytokines: New Insights into the Complex Roles of IL-2 as a Broad Regulator of T helper Cell Differentiation (2011, background): “IL-2 and Th1 differentiation As noted above, Th1 cells secrete IFNg to promote the eradication of intracellular pathogens [21,22].”
• Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages (2005, background): “Substantial advances have been made in understanding the developmental pathways that give rise to T H 1 and T H 2 cell”
• Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. (2009, background): “Depending on signals from innate immune cells induced by various pathogenic agents, naive CD4 T cells differentiate into one of several effector fates including T helper 1 (Th1), Th2, and Th17 cells (Ansel et al., 2006; Murphy and Reiner, 2002; Szabo et al., 2003; Weaver et al., 2007; Zhu and Paul, ”
• A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 (2005, background): “In addition to TCR and costimulatory molecules, IL-12 produced by activated APCs is critical in T H 1 differentiatio”
• New insights into the regulation of T cells by γc family cytokines (2009, neutral): “T H 1 cell differentiation depends mainly on APC-derived IL-12, which leads to IFNγ production and increased IL-12Rβ2 expression by APC”