Naive and primed pluripotent states.

By Jennifer Nichols, Austin G Smith. Cell Stem Cell, 2009

1,855 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/85c0928b6959280f9913e8b2b7e78fdcee91ac26

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Wnt signaling in development and tissue homeostasis (2018, background): “…in promoting pluripotency in the naive state (Sato et al., 2004; ten Berge et al., 2011; Xu et al., 2016) and differentiation in the primed state (Davidson et al., 2012; Kurek et al., 2015), which is characterized by a distinct epigenetic and gene expression landscape (Nichols and Smith, 2009).”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “In this regard, it has been suggested that the pluripotent state can be classified in two different ways: ICM-like or “naïve” state, and epiblast-like or “primed” state (Hanna et al., 2010; Nichols and Smith, 2009).”
SOX17 is a Critical Specifier of Human Primordial Germ Cell Fate (2014, background): “Because there are evident differences between the regulation of mouse and human pluripotent ESCs (Hackett and Surani, 2014; Nichols and Smith, 2009) and during their early postimplantation development (de Fellici, 2013; De Miguel et al., 2010; Irie et al., 2014), this might affect the mechanism and…”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “Murine ESCs established from the ICM of preimplantation blastocysts in the presence of LIF and BMP exist in a more primitive or ‘‘naı̈ve’’ pluripotent state and fulfill all criteria of pluripotency (Table 1; Nichols and Smith 2009).”
Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells. (2011, neutral): “A comprehensive comparison of genetic and epigenetic properties among ESCs, EpiLCs, and EpiSCs would lead to a better understanding of the naive and primed pluripotency (Nichols and Smith, 2009).”
Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo (2009, background): “Neither human ES cells nor EpiSCs exhibit X chromosome reactivation when cultured in 3i/2i, and ultimately fail to survive (Nichols and Smith, 2009).”
Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency (2014, positive): “The morphological, molecular, and functional similarity between human ESCs and mouse postimplantation epiblast-derived EpiSCs has prompted widespread interest in capturing the equivalent of a naive pluripotent stem cell in humans (De Los Angeles et al., 2012; Nichols and Smith, 2009).”
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. (2010, background): “This block in PE formation by FGF inhibition is supported by another recent study (Nichols et al., 2009).”
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs (2010, background): “mESCs and mEpiSCs are molecularly and epigenetically distinct and therefore represent discrete pluripotent states recently termed naïve and primed pluripotent states, respectively (5).”
Nanog Is the Gateway to the Pluripotent Ground State (2009, neutral): “This is a transcriptionally and epigenetically differentiated cell state compared with naive epiblast or ES cells (Nichols and Smith, 2009) that does not revert, even in 2i/LIF.”
Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues (2010, neutral): “Induced pluripotent stem cells (iPSCs) are derived by direct reprogramming of somatic cells in vitro. and Nanog, and they exist in a pre-X-inactivation state with both X chromosomes active in female cells (Nichols and Smith, 2009).”
Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human (2014, methodology): “Disposition to collapse reflects the transient nature of naive pluripotency in the embryo (Nichols and Smith, 2009).”