Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells

By S. Masui, Yuhki Nakatake, Yayoi Toyooka, Daisuke Shimosato, Rika Yagi, Kazue Takahashi, H. Okochi, A. Okuda, R. Matoba, A. Sharov and 2 more. Nature Cell Biology, 2007

1,320 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fd88048a9f60819550211445cb4f97f63a1265cf

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Citations in the corpus

The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate (2013, positive): “This nonessential role contrasts with a requirement for Oct4 during cell fusionmediated reprogramming and might suggest that Oct4 can compensate for the loss of Sox2 in this context, similar to what was seen in self-renewing ESCs (Masui et al., 2007).”
A core Klf circuitry regulates self-renewal of embryonic stem cells (2008, background): “Oct4 and Sox2 have been shown to be critical for the self-renewal state of ES cell”
Production of offspring from a germline stem cell line derived from neonatal ovaries (2009, background): “, Sox-2 (a key transcription factor in regulating stemness related to pluripotency”
Sox2+ adult stem/progenitor cells are important for tissue regeneration and survival of mice (2011, neutral): “Embryos deficient for Sox2 lack a pluripotent ICM and fail early in development, while deletion of Sox2 in ESCs results in their inappropriate differentiation into trophectoderm-like cells (Masui et al., 2007).”
A fresh look at iPS cells. (2009, background): “Inactivation of Sox2 leads to ES cell differentiation, but the forced expression of Oct3/4 rescues this phenotype (Masui et al., 2007).”
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. (2012, background): “…into trophoectoderm-like cells, and it was suggested, consistent with our hypothesis, that Sox2 contributes to the activation of Oct4 by 1220 Cell 150, 1209–1222, September 14, 2012 ª2012 Elsevier Inc. maintaining high levels of orphan nuclear receptors like Nr5a2 (Lrh1) (Masui et al., 2007).”
A Small Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog (2009, result): “Consistent with these data, work by Niwa and co-workers using inducible Sox2-null mES cells demonstrated that Sox2 is dispensable for modulation of the Oct-Sox enhancers that regulate pluripotent-specific gene expression and instead mainly governs pluripotency in ES cells by regulating the expressio”
Mechanisms of stem cell self-renewal. (2009, background): “Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.”
Control of Embryonic Stem Cell State (2011, background): “Oct4 functions as a heterodimer with Sox2 in ESCs, thus placing Sox2 among the key regulators (Ambrosetti et al., 2000; Avilion et al., 2003; Masui et al., 2007).”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “Oct4 and Sox2 can heterodimerise and control expression of a number of genes including Oct4, therefore one of Sox2 functions in maintaining pluripotency seems to be the regulation of Oct4 levels (Masui et al., 2007).”
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. (2010, background): “Intriguingly, the gene pair with the strongest inverse correlation among the early ICM (32-cell) cells does not involve TFs at all, but instead encodes the ligand/receptor pair Fgf4 / Fgfr2 (Figure 5A), which is highly signiﬁcant considering their essential role in PE formation (Arman et al., 1998; ”
Strategies and new developments in the generation of patient-specific pluripotent stem cells. (2007, background): “The deletion of Sox2 in ES cells results in trophectoderm differentiation (Masui et al., 2007).”
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration (2011, background): “Although SOX2 has been implicated in the self-renewal of stem cells, one important function is to maintain OCT4 expression at the appropriate levels needed to maintain pluripotenc”