Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis.

By Tsuyoshi Ikura, Vasily Ogryzko, M. Grigoriev, R. Groisman, Jin Wang, Masami Horikoshi, R. Scully, J. Qin, Yoshihiro Nakatani. Cell, 2000

1,076 citations recorded by the source corpus.

Subfields: Biotechnology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9327f03a0d0d60166027fa7472da53c08944c5fb

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In Molecular Biology

1. T. Halazonetis
2. Li-Huei Tsai
3. Y. Nakatani
4. Kyle D Mansfield
5. J. Sawada
6. L. Pan
7. R. Madabhushi
8. S. Berger

Citations in the corpus

• DNA double-strand breaks: signaling, repair and the cancer connection (2001, neutral): “In this regard it is noteworthy that another protein related to ATM, TRRAP, is a component of TIP60 histone acetylase comple”
• The emerging genetic and molecular basis of Fanconi anaemia (2001, neutral): “Furthermore, BRCA1 also associates with the large protein complexes that function in chromatin remodellin”
• DNA damage and its links to neurodegeneration (2014, positive): “MOF, a specific H4K16 HAT, as well as Tip60 and CBP/P300, less specific HATs that acetylate both histone and non-histone proteins, play pivotal roles in DNA repair (Das et al., 2009; Ikura et al., 2000; Li et al., 2010).”
• Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. (2001, positive): “Thus, p53 bearing substi- tutions in the acetylation sites is still able to bind to its Tip60-containing complexes (Ikura et al., 2000).”
• The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (2003, positive): “…DDB2 Complex Binds Tightly to Chromatin HeLa cells; we detected no polypeptides by silver stain- in a UV-Dependent Manner ing (data not shown; see Ikura et al., 2000; Ogawa et To better understand how DDB2 contributes to GGR, al., 2002), indicating that all detectable polypeptides we attempted…”
• Acetylation of the p53 DNA-binding domain regulates apoptosis induction. (2006, neutral): “The highly related hMOF and TIP60 proteins have been implicated in regulating several critical steps in the DNA damage response (Gupta et al., 2005; Ikura et al., 2000; Kusch et al., 2004; Legube et al., 2002; Sun et al., 2005).”
• Principles for modulation of the nuclear receptor superfamily (2004, neutral): “Using the yeast two-hybrid screen, one of our laboratories found that Tat-interactive protein 60 kDa (Tip60) — a co-activator with histone acetyl transferase activity that interacts with several other transcription factor”
• HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention (2007, neutral): “Moreover, Tra1 and TRRAP are subunits of yeast Esa1 (essential Sas2-related acetyltransferase 1) and human TIP60 complexes, respectively (Allard et al., 1999; Ikura et al., 2000).”
• Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. (2010, neutral): “SAGA was shown to regulate various stress-response genes (Huisinga and Pugh, 2004; Nagy et al., 2010), while TRRAP-containing complex NuA4 regulates apoptosis (Ikura et al., 2000; Tyteca et al., 2006).”
• Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes (2009, neutral): “Tip60 can acetylate H2AK5, H3K14, and H4K5, K8, K12, K16 (Ikura et al., 2000), whereas both Drosophila and human MOF are specific for H4K16 acetylation (Dou et al., 2005).”