DNA damage and its links to neurodegeneration

By R. Madabhushi, L. Pan, Li-Huei Tsai. Neuron, 2014

595 citations recorded by the source corpus.

The integrity of our genetic material is under constant attack from numerous endogenous and exogenous agents. The consequences of a defective DNA damage response are well studied in proliferating cells, especially with regards to the development of cancer, yet its precise roles in the nervous system are relatively poorly understood. Here we attempt to provide a comprehensive overview of the consequences of genomic instability in the nervous system. We highlight the neuropathology of congenital syndromes that result from mutations in DNA repair factors and underscore the importance of the DNA damage response in neural development. In addition, we describe the findings of recent studies, which reveal that a robust DNA damage response is also intimately connected to aging and the manifestation of age-related neurodegenerative disorders such as Alzheimer’s disease and amyotrophic lateral sclerosis.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8146816350f30bc5961eab8b55e22841c8819681

Citations in the corpus

• Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes (2015, unknown): “…has been linked to various neurological disorders, and we previously described the formation of DNA lesions, particularly DNA DSBs, to be an apical neurotoxic event in several mouse models of neurodegeneration (Dobbin et al., 2013; Kim et al., 2008; Madabhushi et al., 2014; Wang et al., 2013).”