Principles for modulation of the nuclear receptor superfamily

By H. Gronemeyer, Jan-Ake Gustafsson, V. Laudet. Nature reviews. Drug discovery, 2004

1,193 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/cd8619918c582dccdff27f6267b4f9524133fe9a

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Citations in the corpus

Child health, developmental plasticity, and epigenetic programming. (2011, neutral): “Their action involves several mechanisms (441).”
Overview of Nomenclature of Nuclear Receptors (2006, background): “Nuclear receptors (NRs 1 ) are members of a large superfamily of evolutionarily related DNA-binding transcription factors that regulate programs involved in a broad spectrum of physiological phenomena (Laudet and Gronemeyer, 2002; Gronemeyer et al., 2004; Chambon, 2005; Evans, 2005).”
Long Noncoding RNAs: Past, Present, and Future (2013, background): “These receptors in turn exert their function on downstream targets by recruiting additional transcription and epigenetic factors, 658 J. T. Y. Kung, D. Colognori, and J. T. Lee including ATP-dependent chromatin remodeling complexes and histone acetyltransferases (HATs) (Gronemeyer et al. 2004).”
Functional Selectivity and Classical Concepts of Quantitative Pharmacology (2007, background): “…to note that, although this Perspective has taken a GPCR-centric view of the receptor world, we are keenly aware that similar phenomena (e.g., selective estrogen receptor modulation) have been recognized with other receptor superfamilies (e.g., see Gronemeyer et al., 2004 for recent review).”
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. (2006, background): “…most successful targets for drugs currently available or being developed to treat a multitude of therapeutic indices, including hypertension, cancer, diabetes, cardiovascular disease, cholesterol gallstone disease, and the metabolic syndrome (Gronemeyer et al., 2004; Shulman and Mangelsdorf, 2005).”
Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor. (2015, methodology): “The model was based on the series of molecular events that typically occur in a nuclear receptor-mediated response (Gronemeyer et al. , 2004; Mangelsdorf et al. , 1995).”
Turning a hobby into a job: How duplicated genes find new functions (2008, background): “; MR receptors bind the hormone aldosterone, whereas GR receptors bind cortiso”
Recent applications of protein crystallography and structure-guided drug design. (2005, background): “Nuclear receptors Typically, members of the nuclear receptor (NR) superfamily are considered ligand-regulated transcription factors, and all the crystallographic work for SGDD to date involves the structurally conserved ligand-binding domain [31].”