The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.
By R. Groisman, J. Polanowska, I. Kuraoka, J. Sawada, M. Saijo, R. Drapkin, A. Kisselev, Kiyoji Tanaka, Y. Nakatani. Cell, 2003
780 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/3c1af994d5c99e26a1d6aceaac9fe28cdee47118
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In Genetics
In Molecular Biology
- Ralf Herwig
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Citations in the corpus
- The General Transcription Machinery and General Cofactors (2006, background): “The 146 M. C. Thomas and C.-M. Chiang XPB helicase activity is essential for promoter clearance, which typically occurs within formation of the first 20 nucleotides and defines the transition from initiation and elongation.”
- Structure and function of WD40 domain proteins (2011, background): “CUL4-DDB1-ROC1 complex is another E3 ubiquitin ligase (Groisman et al., 2003; He et al., 2006; Higa et al., 2006).”
- Nucleotide excision repair in eukaryotes. (2013, background): “UV-DDB forms part of a ubiquitin ligase complex with CUL4A and ROC1 (Groisman et al. 2003) that localizes to chromatin immediately after UV irradiation, in which it ubiquitinates histone H2A, H3, and H4 resulting in a destabilization of the nucleosome structure (Bergink et al.”
- The ConsensusPathDB interaction database: 2013 update (2012, background): “The module also includes gene sets centered at several ubiquitin E3 ligases: COP1 [gene symbol: RFWD2, a negative regulator of p53 (39)], RBX1 (Gene Ontology annotation: DNA repair) and DDB2 complex [involved in DNA repair (40)].”
- A genomic and functional inventory of deubiquitinating enzymes. (2005, neutral): “USP21 and UCH-L3 cleave both Ub and the Ubl molecule NEDD8.”
- Systematic analysis and nomenclature of mammalian F-box proteins. (2004, background): “Cul4 forms a complex wherein DDB1/DDB2 and CSA proteins appear to function as substrate specificity modules (Groisman et al. 2003).”
- CSN controls NF‐κB by deubiquitinylation of IκBα (2007, background): “Cullin 1 (Cul1) and all other cullins identified so far (Lyapina et al, 2001; Schwechheimer et al, 2001; Zhou et al, 2001; Groisman et al, 2003; Liu et al, 2003; Pintard et al, 2003) represent the best-characterised substrates for dened- dylase activity of the CSN.”