Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases.

By N. Barlev, Lin Liu, N. Chehab, Kyle D Mansfield, Kimberly G. Harris, T. Halazonetis, S. Berger. Molecules and Cells, 2001

742 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/cb08121f42118eaff5e6f69f8b00e595621f0ece

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. W. Gu
2. Carol Prives
3. D. Reinberg
4. E. Verdin
5. Tony Kouzarides
6. C. Brooks
7. Paul Tempst
8. Yingming Zhao

In Oncology

1. Carol Prives
2. W. Gu
3. C. Brooks
4. Yingming Zhao
5. Yi Tang
6. Tony Kouzarides
7. Yue Chen
8. Wenhui Zhao

Citations in the corpus

• Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. (2003, background): “Indeed, p53 acetylation is critically important both for the efficient recruitment of these complexes to promoter regions and the activation of p53 target genes in vivo [62 ].”
• Transcriptional control of human p53-regulated genes (2008, background): “Investigators have shown that p53 needs post-translational modifications in the C-terminal domain to bind to naked DNA in vitro , but requires no modifications in the presence of chromatin to bind to p53 RE”
• The complexity of p53 stabilization and activation (2006, background): “induced phosphorylation of p53 increases its association with CBP/p300 transcriptional coactivators and as a consequence it increases p53 acetylation and leads to increased stability.(37,85) Under unperturbed conditions, MDM2 prevents interaction between p53 and p300.”
• Acetylation is indispensable for p53 activation. (2008, background): “The acetylation levels of p53 are significantly enhanced in response to stress and correlate well with p53 activation and stabilization (Luo et al., 2000, 2001; Vaziri et al., 2001; Ito et al., 2001; Barlev et al., 2001; Knights et al., 2006; Li et al., 2007; Zhao et al., 2008; Kim et al., 2008).”
• Regulation of p53 activity through lysine methylation (2004, background): “and potentiates its interaction with other transcription factor”
• p300/CBP and cancer (2004, background): “Furthermore, p300 is required for p53-mediated transactivation of target genes through its coactivator function and acetylation of target gene histones (Avantaggiati et al., 1997; Lill et al., 1997; Barlev et al., 2001; Espinosa and Emerson, 2001).”
• Post-translational modification of p53 in tumorigenesis (2004, background): “Acetylation seems to be important for p53 stability and transcriptional activatio”
• Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans (2004, methodology): “for nucleosomal HAT activity, full-length Tip60, Tip60b, ING3, ING3(1-300),”
• Sirtuins: critical regulators at the crossroads between cancer and aging (2007, background): “In response to stress signals, p53 is acetylated at multiple lysines, which enhances its activity and stability (Barlev et al., 2001).”