Acetylation of the p53 DNA-binding domain regulates apoptosis induction.

By Stephen M Sykes, H. Mellert, Marc A. Holbert, Keqin Li, R. Marmorstein, William Arbuthnot Sir Lane, S. McMahon. Molecules and Cells, 2006

776 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/57c122427f5734aa9db293aee7873de8b5177cc5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Jiandong Chen
2. W. Gu
3. Xiang-Jiao Yang
4. E. Seto
5. Karen H. Vousden
6. Carol Prives
7. Yingming Zhao
8. Yi Tang

In Oncology

1. W. Gu
2. Jiandong Chen
3. E. Seto
4. Karen H. Vousden
5. Yingming Zhao
6. Carol Prives
7. Yi Tang
8. Xiang-Jiao Yang

Citations in the corpus

• Acetylation is indispensable for p53 activation. (2008, background): “Following our early findings of C terminus p53 acetylation, we and others recently showed that p53 is also acetylated by Tip60/hMOF at residue K120 within the DNA-binding domain (Tang et al., 2006; Sykes et al., 2006).”
• Tumor suppression in the absence of p53-mediated cell cycle arrest, apoptosis, and senescence (2012, neutral): “We and others recently showed that p53 is acetylated at K120 by Tip60/MOF (Sykes et al., 2006; Tang et al., 2006; Li et al., 2009), whereas K164 is acetylated by CBP and p300, but not Tip60/MOF (Tang et al.”
• Blinded by the Light: The Growing Complexity of p53. (2009, background): “Two MYST family histone acetyl transfereases (HATs)—Tip60 (Tang et al., 2006) and hMOF (Sykes et al., 2006)—are capable of acetylating K120.”
• The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression. (2016, background): “Acetylation of K120 in the DNAbinding domain by acetylases Tip60 or hMOF specifically promotes apoptosis (Sykes et al. 2006; Tang et al. 2006).”
• HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention (2007, background): “For example, p300, PCAF and two members of the MYST family acetylate p53 (Gu and Roeder, 1997; Sakaguchi et al., 1998; Liu et al., 1999; Sykes et al., 2006; Tang et al., 2006).”
• Lysine acetylation: codified crosstalk with other posttranslational modifications (2008, background): “Moreover, its acetylation lies at the nexus of apoptotic and cell-cycle control (Sykes et al., 2006; Tang et al., 2006), so it will be interesting to determine if K117R mutant mice display more dramatic phenotypes.”