Toll-like receptors in the pathogenesis of human disease

By D. Cook, D. Pisetsky, David A. Schwartz. Nature Immunology, 2004

911 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/90f9024bbf8fa3ee6b353332c3a58718f8dba3f1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Emergency Medical Services

1. A. O’Garra

In Immunology

1. T. Kanneganti
2. G. Núñez
3. L. Franchi
4. N. Warner
5. Luke A. O'Neill
6. N. Inohara
7. A. O’Garra
8. C. Hawrylowicz

In Physiology

1. G. Núñez
2. Esther M. Sternberg
3. L. Franchi
4. Luke A. O'Neill
5. C. A. Dinarello

Citations in the corpus

• Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma (2005, background): “Indeed, T H 1 responses can also promote lung inflammation, and evidence from animal models and from human disease indicates that T H 1 responses can induce allergic sensitization and/or exacerbate existing inflammatio”
• Negative regulation of Toll-like receptor-mediated immune responses (2005, background): “However, members of the TLR family are also involved in the pathogenesis of autoimmune, chronic inflammatory and infectious disease”
• Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “However, overproduction of these cytokines via stimulation of innate immune cells with TLR ligands is harmful to the host and can lead to septic shock and multi-organ failure (91, 92).”
• Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21 (2010, background): “or for inflammation in processes such as sepsis, rheumatoid arthritis and allergic asthm”
• MicroRNAs: the fine-tuners of Toll-like receptor signalling (2011, background): “It has also been recognized that dysregulation of this process is a hallmark of inflammatory and autoimmune disease”
• Pathogen recognition and innate immunity. (2006, neutral): “Interestingly, two cosegregating missense mutations, Asp299Gly and Thr399Ile, have been found in the human TLR4 gene (Cook et al., 2004).”
• Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens (2006, background): “The cellular and molecular components of the innate immune system provide the first line of defence against invading pathogen”
• Ligand-induced endocytosis of the pattern recognition receptor FLS2 in Arabidopsis. (2006, background): “It has been reported that uncontrolled hyperinduction of proinflammatory cytokines by TLRs may play a role in the pathogenesis of autoimmune, chronic inflammatory, and infectious diseases (Cook et al. 2004).”
• Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages (2006, background): “Although appropriate amounts of these cytokines are critical for cell-mediated bacterial killing and activation of adaptive immunity, cytokines induce positive feedback in the immune system, and excessive production of cytokines can lead to severe immunopatholog”
• The immunology of sepsis (2008, background): “Furthermore, humans with polymorphisms in TLR2 have altered responsiveness to TLR2 ligands [32], although a missense point mutation in NOD2 is associated with Crohn’s disease susceptibility rather than susceptibility to sepsis.”
• Aspects of immune dysfunction in end-stage renal disease. (2008, background): “Patients with a loss of function in the TLR4 gene are more susceptible to infections with Gram-negative bacteria (14).”