Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

By Frederick J. Sheedy, E. Palsson-McDermott, E. J. Hennessy, Cara M. Martin, J. O'Leary, Qingguo Ruan, Derek S. Johnson, Youhai H. Chen, Luke A. O'Neill. Nature Immunology, 2010

1,055 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/0156ba1fd362b89d351855c451dcb604b2447d34

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Citations in the corpus

microRNA regulation of inflammatory responses. (2012, background): “More recent data suggest that such negative feedback regulation may also apply to miR-21 (41).”
MicroRNAs: the fine-tuners of Toll-like receptor signalling (2011, background): “In our studies of the induction of miR-21 by LPS, we identified the tumour suppressor protein programmed cell death 4 (PDCD4) as a key target that is downregulated by miR-21 during TLR4 signalling in macrophage”
Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance (2014, background): “It has been reported that miR-98 and miR-21 inhibit the expression of inflammatory genes in monocytes and macrophages via controlling IL-10 level (88, 89).”
Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4 (2012, background): “Moreover, TLR4 can be negatively regulated by intracellular inhibitors, membrane-bound suppressors, receptor degradation, TLR-induced apoptosis, and microRNAs (Liew et al., 2005; Sheedy et al., 2010).”
Pattern recognition receptors and inflammation. (2010, background): “A recent report shows that miR-21 negatively regulates TLR4 signaling by the tumor suppressor PDCD4, a protein required for NF-kB activation (Sheedy et al., 2009).”