Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma

By C. Hawrylowicz, A. O’Garra. Nature reviews. Immunology, 2005

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Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. (2005, background): “We would argue that the challenge for the future will be to harness these beneficial drug-mediated effects and induce allergen-specific IL-10 synthesis in a local and controlled manner at the time of allergen exposure (6).”
How regulatory T cells work (2008, result): “However, this is in contrast with data from in vivo studie”
The regulation of IL-10 production by immune cells (2010, background): “Interleukin-10 ( IL-10 ) is an anti-inflammatory cytokine with a crucial role in preventing inflammatory and autoimmune pathologie”
The development of allergic inflammation (2008, background): “Such mechanisms include the development of regulatory T cells that secrete interleukin 10 (IL-10), which has many immunosuppressive and anti-inflammatory effect”