Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

By L. Franchi, A. Amer, Mathilde Body-Malapel, T. Kanneganti, Nesrin Özören, R. Jagirdar, N. Inohara, Peter Vandenabeele, J. Bertin, A. Coyle and 2 more. Nature Immunology, 2006

1,210 citations recorded by the source corpus.

Subfields: Endocrinology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e7c2162ce1426b311ad31482ece08fc038fe40ce

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. J. Tschopp
2. G. Núñez
3. S. Ghosh
4. D. Monack

In Immunology

1. T. Kanneganti
2. J. Tschopp
3. M. Lamkanfi
4. S. Ghosh
5. Kate Schroder
6. G. Núñez
7. V. Dixit
8. M. Hayden

In Molecular Biology

1. T. Kanneganti
2. M. Lamkanfi
3. J. Tschopp
4. G. Núñez
5. Kate Schroder
6. V. Dixit
7. S. Man
8. L. Franchi

Citations in the corpus

• Regulation of inflammasome activation (2015, background): “The mouse NLRC4 inflammasome is activated by flagellin (124, 125) and the inner rod proteins of the Type III secretion system of S.”
• Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “Caspase1 is essential for the early induction of cell death, membrane swelling, and IL-1b production in macrophages infected with Salmonella (149, 215), Pseudomonas (154), Shigella (152), Listeria (216), Legionella (155), or when macrophages are stimulated with anthrax LT (217) or with ATP (218, 219”
• Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing (2010, background): “Nlrc4 activates Caspase-1 after infection with Salmonella spp., Pseudomonas aeruginosa, Listeria monocytogenes, and Legionella pneumophila (Amer et al., 2006; Franchi et al., 2006; Miao et al., 2006; Ren et al., 2006).”
• Pyroptotic cell death defends against intracellular pathogens (2015, background): “Given this conservation, flagellin is recognized and accidentally secreted by a T3SS that normally delivers bacterial effectors to the host cytosol where it is efficiently detected by NLRC4 (20, 21) (Fig.”
• NLRP3 (NALP3/CIAS1/Cryopyrin) mediates key innate and healing responses to influenza A virus via the regulation of caspase-1 (2009, positive): “Salmonella and Legionella flagellin are sensed by the Ipaf inflammasome (Amer et al., 2006; Franchi et al., 2006; Miao et al., 2006), whereas Cryopyrin mediates caspase-1 activation in response to a wide variety of microbial components including dsRNA and viral RNA or its analog poly(I:C)…”