Mechanisms of sensory transduction in the skin

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Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia (2009, background): “…Merkel cells, hair cells) could be involved in the signal transduction from the apical part to the basolateral part, where transmembrane channels or transmitter-containing vesicles are opened to release signaling molecules transducing the signal to associated neurons (Lumpkin & Caterina, 2007).”
Nociceptors: the sensors of the pain pathway. (2010, background): “Nociceptive endings are in the vicinity of keratinocytes, mast cells, and Langerhans cells, indicating the capacity of peripheral sensory endings to monitor the status of the skin (31).”
Cellular and Molecular Mechanisms of Pain (2009, neutral): “What accounts for the TRPV1-independent component of heat sensation? A number of other TRPV channel subtypes, including TRPV2, 3, and 4, have emerged as candidate heat transducers that could potentially cover detection of stimulus intensities flanking that of TRPV1, including both very hot (>50°C) a”