Local force and geometry sensing regulate cell functions

By Viola Vogel, M. Sheetz. Nature reviews. Molecular cell biology, 2006

2,312 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Cell Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/5e04167644b44cb057abad51932316bd8d18ac12

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Atomic and Molecular Physics, and Optics

In Cell Biology

In Physiology

Citations in the corpus

Myosin II dynamics are regulated by tension in intercalating cells (2009, background): “How is mechanical tension translated into myosin II stabilization at the cortex? Evidence from the literature suggests three models of mechanotransduction (Vogel and Sheetz, 2006).”
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus (2009, background): “It is commonly known in the field that when a physical force is applied to the cell surface, it distorts the membrane cortex and then quickly dissipates into the cytoplas”
Physics of adherent cells (2013, background): “During recent years, it has become increasingly clear that the cell-material interface determines the behavior and fate of biological cells to a much larger extent than was formerly appreciated (Discher, Janmey, and Wang, 2005; Schwarz and Bischofs, 2005; Vogel and Sheetz, 2006; Discher, Mooney, and”
The multiple faces of caveolae (2007, background): “Caveolae as mechanosensors One of the most exciting insights into caveola function that has been derived from the use of caveolin-null mice and knockdown systems is the demonstration of a role for caveolae in mechanosensation (for a review see Ref”
Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae (2011, background): “Because several of these effectors have been associated with mechanotransduction (Vogel and Sheetz, 2006), stress-induced disassembly of caveolae may generate mechanosensitive signals mediating the short- and long-term cell response to mechanical challenges.”
Mechanotransduction gone awry (2009, background): “As such, mechanotransduction — be it involved in sensing externally applied forces (for example, in touch sensation) or in regulating forces and tension in the body (for example, in muscle tension or regulation of blood pressure) — is essential to developmental pathways and to normal tissue homeosta”
Modeling tissue morphogenesis and cancer in 3D. (2007, neutral): “Cell surface integrin receptors and the contractile cytoskeleton pull against the extracellular matrix to sense the stiffness of the microenvironment (Ghosh et al., 2007; Ingber, 2006; Vogel and Sheetz, 2006).”
Formation and function of the myofibroblast during tissue repair. (2007, background): “…mechanisms of mechano-sensing are conceivable: (1) mechano-sensitive ion channels in the plasma membrane (Martinac, 2004), (2) integrin-mediated stress perception (Katsumi et al., 2004), and (3) geometry changes that reveal cryptic signaling domains in proteins of the ECM (Vogel and Sheetz, 2006).”