Mechanotransduction in vascular physiology and atherogenesis

By Cornelia S. Hahn, M. Schwartz. Nature reviews. Molecular cell biology, 2009

1,204 citations recorded by the source corpus.

Forces that are associated with blood flow are major determinants of vascular morphogenesis and physiology. Blood flow is crucial for blood vessel development during embryogenesis and for regulation of vessel diameter in adult life. It is also a key factor in atherosclerosis, which, despite the systemic nature of major risk factors, occurs mainly in regions of arteries that experience disturbances in fluid flow. Recent data have highlighted the potential endothelial mechanotransducers that might mediate responses to blood flow, the effects of atheroprotective rather than atherogenic flow, the mechanisms that contribute to the progression of the disease and how systemic factors interact with flow patterns to cause atherosclerosis.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/09779aaee535ba4d1c0e427d6504177d0ec95315

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In Cardiology and Cardiovascular Medicine

J. Chiu

In Molecular Biology

In Pulmonary and Respiratory Medicine

Shu Chien

Citations in the corpus

Dynamic molecular processes mediate cellular mechanotransduction (2011, neutral): “In the vasculature, blood flow exerts fluid shear stresses on the endothelial cells lining the vessels, whereas blood pressure stretches the vessel wal”
Mechanotransduction gone awry (2009, background): “Consistent with this idea, atherosclerotic lesions are often found at specific sites of disturbed (that is, turbulent) flow patterns, characterized by low and oscillatory shear stress at the endothelium (see the Review by Hahn and Schwart”
The blood-brain barrier: an engineering perspective (2013, background): “These stresses play an important role in regulating endothelial cell morphology and function, and in mediating a wide range of signaling and transport processes between the vascular system and surrounding tissue (Chien, 2007; Hahn and Schwartz, 2009; Johnson et al., 2011; Conway and Schwartz, 2012).”
Engineering microscale topographies to control the cell–substrate interface (2012, background): “Indeed, mechanical factors are present during embryogenesis and development [169], in adult life, and are involved in many pathological conditions [70], such as atherosclerosis [170], osteoporosis [171], myopathies [172], and cancer [173].”
Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives (2011, background): “There is increasing evidence that various hemodynamic forces, including fluid shear stress, can also influence the structure and function of ECs and modulate their expressions of pathophysiologically relevant genes (74, 87, 93, 125, 131, 153, 203, 211, 213, 230, 240, 279, 282, 337, 571, 625).”
Monocytes in atherosclerosis: subsets and functions (2010, background): “Interestingly, this process occurs in atherosclerosis-prone areas of the arterial tree, such as artery branches, and is very likely to involve cellular responses to changes in fluid dynamics (discussed below)”
Piezo1, a mechanically activated ion channel, is required for vascular development in mice (2014, background): “Impairment in mechanotransduction can lead to a wide range of pathologies including deafness and atherosclerosis (5, 6).”
Mechanobiology of YAP and TAZ in physiology and disease (2017, background): “YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29.”