Mechanisms of mechanotransduction.

By A. Orr, B. Helmke, B. Blackman, M. Schwartz. Developmental Cell, 2006

822 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8f8594d50617afef7fce5610a246c1ef83b9af55

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Citations in the corpus

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues (2012, background): “…number of adhesions are among the better understood signals that are integrated by the cell in order to regulate many fundamental cellular behaviors, including survival, differentiation, proliferation and migration (Wozniak et al., 2004; Weber et al., 2011; Orr et al., 2006; Geiger et al., 2009).”
Nanoparticles in tissue engineering: applications, challenges and prospects (2018, neutral): “mechanotransduction pathways.(101) Numerous approaches”
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus (2009, background): “As expected, surface-membrane receptors — such as integrins and cadherins, which mediate cell adhesion to extracellular matrix (ECM) scaffolds and to neighbouring cells, respectively — have a central role in mechanotransductio”
Integrins and extracellular matrix in mechanotransduction. (2010, background): “A great many studies have catalogued the effects of stretch or other forces on gene expression and cellular phenotype (Chiquet et al. 2003; Orr et al. 2006).”
Mechanical control of tissue and organ development (2010, background): “However, great advances have been made in this field of mechanotransduction over the past two decades (reviewed by Ingber, 2006; Orr et al., 2006).”
Modeling tissue morphogenesis and cancer in 3D. (2007, neutral): “Numerous studies have analyzed the bidirectional mechanosensory responses of fibroblasts or myofibroblasts to collagen gels (Cukierman et al., 2002; Discher et al., 2005; Ghosh et al., 2007; Grinnell, 2003; Orr et al., 2006).”
Mechanotransduction in vascular physiology and atherogenesis (2009, background): “Many putative mechanotransducers have been proposed to function in sensing flow, including ion channels, integrins, receptor Tyr kinases, the apical glycocalyx, primary cilia, heterotrimeric G proteins, platelet/endothelial cell-adhesion molecule 1 ( PECAM1 ) and vascular endothelial (VE)-cadheri”
Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives (2011, background): “These findings suggest that disturbed and laminar flow patterns may induce differential molecular responses in ECs to result in, respectively, the preferential localization of atherosclerotic lesions at arterial branches and curvatures and the sparing of the straight parts of the arterial tree (135,”
Mechanotransduction gone awry (2009, background): “Cells need to feel the force All cells and organisms across the evolutionary spectrum, from the most primitive to the most complex, are mechanosensitiv”
Mechanical control of stem cell differentiation (2008, background): “Shear stress is perhaps best known for its effects on the vascular endothelium (Davies, 1995; Orr et al., 2006).”
Myosin II dynamics are regulated by tension in intercalating cells (2009, background): “First, forces have been shown to influence gene expression in normal cells as well as during tumorigenesis (Orr et al., 2006; Wozniak and Chen, 2009), suggesting that tension could lead to changes in the expression of myosin II regulatory proteins.”
Dynamic molecular processes mediate cellular mechanotransduction (2011, neutral): “jpg"/> There is growing recognition that mechanical factors, such as applied forces or the rigidity of the extracellular matrix (ECM), crucially influence the form and function of cells and organism”