Dynamic molecular processes mediate cellular mechanotransduction

By B. Hoffman, C. Grashoff, M. Schwartz. Nature, 2011

944 citations recorded by the source corpus.

Cellular responses to mechanical forces are crucial in embryonic development and adult physiology, and are involved in numerous diseases, including atherosclerosis, hypertension, osteoporosis, muscular dystrophy, myopathies and cancer. These responses are mediated by load-bearing subcellular structures, such as the plasma membrane, cell-adhesion complexes and the cytoskeleton. Recent work has demonstrated that these structures are dynamic, undergoing assembly, disassembly and movement, even when ostensibly stable. An emerging insight is that transduction of forces into biochemical signals occurs within the context of these processes. This framework helps to explain how forces of varying strengths or dynamic characteristics regulate distinct signalling pathways.

Subfields: Atomic and Molecular Physics, and Optics, Cell Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/d562c01a3b70113c5fded6b80073b8f7a0b3c0a0

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Citations in the corpus

Geometry and Mechanics of Microdomains in Growing Bacterial Colonies (2017, background): “Although it has been long known that mechanical forces play a critical role in the development and fitness of eukaryotic cells and, in addition, can regulate key molecular pathways [7], the cornerstones of major discoveries in bacterial communities have relied on biochemical pathways triggered exclu”
Physics of adherent cells (2013, background): “In addition, other biochemical changes can modify the response time of the cytoskeleton and thereby control its orientation in response to cyclically varying stress (Hoffman et al., 2011).”
Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration (2012, background): “There is extensive evidence that actomyosin cytoskeletal contractility and integrin engagement to ECM via FAs are required for rigidity mechanosensing (Hoffman et al., 2011).”
Piezo1, a mechanically activated ion channel, is required for vascular development in mice (2014, background): “M the conversion of physical forces into a biochemical response, is an essential signaling mechanism used by all organisms (1).”
Integrin-mediated mechanotransduction (2016, background): “To detect and interpret the biological information in the ECM, cells adhere and transduce myosin-generated traction forces to the ECM via integrin-based adhesions and elicit a series of dynamic signaling events that are jointly termed mechanotransduction (Hoffman et al., 2011).”
The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles. (2012, background): “Although the pathophysiology of hypertension was originally focused on the determinant role of the kidney in the long-term control of body fluid volumes, compelling evidence now suggests that ‘mechanotransduction disorders’ at the level of the VSMC play a role in its genesis.(9) Hypertension and the”
Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues (2012, background): “In addition to sensing passive mechanical cues, such as the compliance of the surrounding matrix, tissues commonly experience a variety of active loads, which result in force transduction and deformation at the cellular level (Hoffman et al., 2011).”