Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

By Ning Wang, J. Tytell, Donald E. Ingber. Nature reviews. Molecular cell biology, 2009

1,752 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Cell Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/b0557687e4adbacb5ab90185e01bb3db585fdfb2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Atomic and Molecular Physics, and Optics

1. Shmuel Safran
2. Donald E. Ingber
3. Ulrich S. Schwarz
4. Marita L. Rodriguez
5. Valerie M. Weaver
6. P. McGarry
7. Nathan J. Sniadecki

In Cell Biology

1. Valerie M. Weaver
2. Pengfei Lu
3. Ulrich S. Schwarz
4. Shmuel Safran
5. Nathan J. Sniadecki
6. Marita L. Rodriguez
7. P. McGarry
8. Zena Werb

In Physiology

1. Valerie M. Weaver
2. T. Mammoto
3. Ulrich S. Schwarz
4. Shmuel Safran
5. Marita L. Rodriguez
6. P. McGarry
7. Nathan J. Sniadecki
8. Matthew J. Dalby

Citations in the corpus

• The Extracellular Matrix In Development and Morphogenesis: A Dynamic View (2009, background): “Integrins coupling to the cytoskeletal network can extend to the nuclear scaffold via the LINK complex, composed of nesprins, sun and lamin proteins (Wang et al., 2009).”
• Review on Cell Mechanics: Experimental and Modeling Approaches (2013, background): “The main role of a cell's nucleus is to regulate gene expression, but it also has a degree of structural stiffness and plasticity that can play a role in cell mechanics and mechanotransduction [20] [21] [22] [23].”
• Mechanical control of tissue and organ development (2010, background): “…to multiple sites in the cell over cytoskeletal linkages, and the efficiency of this signal transfer is sensitive to the level of tensional prestress in the cells, which ‘tunes’ the cellular response, much as mechanical tension tunes a violin string (Box 1) (Wang et al., 2001; Wang et al., 2009).”
• Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency. (2011, background): “It is also likely that direct mechanotransductive events will be involved, for example, through cellular tensegrit”
• Physics of adherent cells (2013, background): “Further experiments and models that explore how CSK stresses translate into nuclear stresses and possibly chromosomal rearrangements (Iyer et al., 2012; Roopa et al., 2008; Wang et al., 2009; Zeng et al., 2011) are needed before conclusions can be drawn.”
• Extracellular Matrix Degradation and Remodeling in Development and Disease (2011, background): “Drosophila MMP-2, for example, is specifically expressed in early fly embryos to facilitate tracheal branching morphogenesis (Wang et al. 2009b).”