Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

By Brendon M. Baker, Christopher S. Chen. Journal of Cell Science, 2012

1,701 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology

View Paper: https://www.semanticscholar.org/paper/0584e90d0817c09666a31db868f35fac899e9d59

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Citations in the corpus

Modeling Physiological Events in 2D vs. 3D Cell Culture. (2017, background): “mechano-responses, and cell survival (2, 10, 41).”
Physical traits of cancer (2020, background): “Normal and cancerous breast epithelial cells have drastically different morphology and growth rates when cultured in 3D matrices but are difficult to distinguish when cultured on 2D surfaces (118).”
Spherical Cancer Models in Tumor Biology (2015, background): “…it is now well admitted that the 3D cell – cell interaction per se influences cell structure, adhesion, mechanotransduction, and signaling in response to soluble factors which in turn regulate overall cell function in ways that differ dramatically from traditional 2D culture formats [3].”
A practical guide to hydrogels for cell culture (2016, background): “Furthermore, these culture systems are typically two dimensional (2D) 1 , whereas cells in the body are likely to receive signals not just at their ventral surface but in all three dimensions.”
A Review of Cell Adhesion Studies for Biomedical and Biological Applications (2015, background): “The ability to grow cells within ECM gels (3D culture) is a major advantage to understand in vivo cellular cell behaviors, ranging from differentiated function to maintenance of stem cell functions [61,62].”
2D and 3D cell cultures – a comparison of different types of cancer cell cultures (2016, background): “Time of culture formation Within minutes to a few hours From a few hours to a few days [11, 34, 57]”