Mechanical control of tissue and organ development
By T. Mammoto, Donald E. Ingber. Development, 2010
841 citations recorded by the source corpus.
Many genes and molecules that drive tissue patterning during organogenesis and tissue regeneration have been discovered. Yet, we still lack a full understanding of how these chemical cues induce the formation of living tissues with their unique shapes and material properties. Here, we review work based on the convergence of physics, engineering and biology that suggests that mechanical forces generated by living cells are as crucial as genes and chemical signals for the control of embryological development, morphogenesis and tissue patterning.
Subfields: Biomedical Engineering, Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8d20b0fcb74fd13edafedccb55896713edc16e2c
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Citations in the corpus
- Soft Robotics: A Perspective—Current Trends and Prospects for the Future (2014, positive): “In tissue growth and engineering, the relative elasticity of contacting tissue can influence how tissue cells move, grow, and differentiate.(3) Mismatches in elastic compliance can lead to damaging stress concentrations, redistribute internal forces in a way that leads to disuse atrophy of bone or t”
- Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “tion [11,13], and that tissue elasticity is altered during aging, disease and injury [18,76].”
- Role of YAP/TAZ in mechanotransduction (2011, methodology): “23 for positive controls) had marginal effect on YAP/TAZ inactivation by mechanical cues, as judged by (1) YAP/TAZ nuclear exit induced by micropatterns or cytoskeletal inhibition in MEC, MSC or HMVEC (Fig.”