Mitochondrial bioenergetics and structural network organization

By G. Bénard, Nadège Bellance, D. James, P. Parrone, H. Fernandez, T. Letellier, R. Rossignol. Journal of Cell Science, 2007

626 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8d2c91a1d6c009d00c027b3a71f68faf7746dbd1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

1. Orian Shirihai
2. Xiongwei Zhu
3. George Perry
4. G. Perkins
5. K. Mihara
6. Li Li
7. Xinglong Wang
8. Hyoung-Gon Lee

In Molecular Biology

1. Guido Kroemer
2. L. Galluzzi
3. Douglas R. Green
4. Orian Shirihai
5. M. Liesa
6. G. Twig
7. K. Mihara
8. M. Palacín

Citations in the corpus

• Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease (2013, positive): “More recently, we and others demonstrated that mitochondrial electron-transport-chain complex inhibitors such as rotenone, 1-methyl-4-phenylpyridinium, and 3-nitropropionic acid cause fragmentation of the mitochondrial network along with increased ROS production [138 – 140].”
• Mitochondrial fragmentation in neurodegeneration (2008, background): “Similarly, blocking DRP1 activity with RNAi in HeLa cells prevented mitochondrial fission and decreased respiratory activity and ATP productio”
• Metabolic control of cell death (2014, positive): “Thus, Dym dissipation favors mitochondrial fragmentation (15).”
• Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure (2013, background): “For example, inhibition of mitochondrial fission through Drp1 modulation impairs mitochondrial function.”
• Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice (2009, result): “2g ), in contrast with the reports for Drp1-knockdown HeLa cell”
• Impaired Balance of Mitochondria Fission and Fusion in Alzheimer Disease (2009, background): “Neurons are particularly vulnerable to mitochondrial dysfunction because of their high metabolic rate dependence and complex morphology (Delettre et al., 2000; Benard et al., 2007).”
• The Interplay Between Mitochondrial Dynamics and Mitophagy (2011, background): “Altered respiration was reported in HeLa cells transfected with Drp1 shRNA (7).”
• Mitochondrial dynamics in mammalian health and disease. (2009, background): “Under these conditions, repression of DRP1 is associated with lower rates of state 4 and state 3 respiration and reduced complex IV activity (25).”
• Reversible phosphorylation of Drp1 by cyclic AMP‐dependent protein kinase and calcineurin regulates mitochondrial fission and cell death (2007, background): “Cell morphology, growth rates and spontaneous cell death were comparable in all cell lines except that GFP–Drp1 Ser656Asp-expressing cell lines proliferated at approximately half the rate of other lines, mirroring the phenotype of HeLa cells depleted of Drp1 by RNAi (Benard et al, 2007).”
• A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. (2012, positive): “In order to ensure maximal mitochondrial activity, we therefore adapted COS7 cells to grow on galactose, a carbon source that requires mitochondrial respiration for energy production [4].”