Neurotrophins as synaptic modulators

By Mu-Ming Poo. Nature Reviews Neuroscience, 2001

1,869 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8c58124fa038c2a770180a768ef56b8df847908a

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In Cellular and Molecular Neuroscience

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Citations in the corpus

TrkB signalling pathways in LTP and learning (2009, background): “, and demonstrated that BDNF influences hippocampal synaptic plasticity through Trk”
The GDNF family: Signalling, biological functions and therapeutic value (2002, background): “Cyclic AMP is an important regulator of neuronal survival, regeneration and growth cone remodelling that are mediated by neurotrophic factor”
Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons (2004, background): “In particular , there is accumulating evidence that activity - dependent release of BDNF rapidly modulates syn - aptic transmission and neural plasticity in a variety of different experimental paradigms ( Poo , 2001 ; Lu , 2003a ) .”
A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. (2002, background): “As discussed, cellular and molecular events involved with these processes are under the range of action of BDNF (Poo, 2001).”
New insights in the biology of BDNF synthesis and release: implications in CNS function (2009, positive): “Indeed, BDNF levels are dynamically regulated in postnatal development, in part by activitydependent mechanisms (Poo, 2001).”
Frontiers in Synaptic Neuroscience Synaptic Neuroscience (positive): “BDNF is produced in excitatory pyramidal neurons, and its expression and release depend on neuronal activity (Poo, 2001).”
Wnts and TGFβ in synaptogenesis: old friends signalling at new places (2003, background): “This synaptic plasticity also depends on communication between pre- and postsynaptic compartment”
Is mood chemistry? (2005, background): “, has been proposed to be a crucial factor in the selection and stabilization of active synaptic contact”
Neurotrophin-regulated signalling pathways (2006, background): “…of neuronal development and function, including synapse formation and synaptic plasticity (Lewin & Barde 1996; Bibel & Barde 2000; Kaplan & Miller 2000; Huang et al. 2001; Poo 2001; Shooter 2001; Sofroniew et al. 2001; Dechant & Barde 2002; Chao 2003; Huang & Reichardt 2003; Lu et al. 2005).”
Neurotrophin secretion: current facts and future prospects. (2003, background): “Today the role of BDNF in long-term synaptic plasticity in the hippocampus and neocortex is well established (reviewed, e.g. inLessmann, 1998; Schuman, 1999; Schinder and Poo, 2000; Poo, 2001), and it will only be briefly summarized here.”
Brain-Derived Neurotrophic Factor val66met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance (2003, background): “…only regulates cell survival, proliferation, and synaptic growth in the developing CNS but also is a critical element in modulating synaptic changes, such as hippocampal long-term potentiation (LTP), associated with learning and adaptive behaviors in adult animals (Poo, 2001; Tyler et al., 2002).”
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. (2006, background): “Although it might seem counterintuitive that the higher levels of BDNF in neurons overexpressing wild-type MeCP2, compared to S421 mutant MeCP2, would contribute to the inhibition of dendritic growth and spine maturation, the effects of BDNF have been shown to be highly context dependent (Poo, 2001)”