New insights in the biology of BDNF synthesis and release: implications in CNS function
By Michael E. Greenberg, Baoji Xu, B. Lu, B. Hempstead. Journal of Neuroscience, 2009
597 citations recorded by the source corpus.
BDNF has pleiotropic effects on neuronal development and synaptic plasticity that underlie circuit formation and cognitive function. Recent breakthroughs reveal that neuronal activity regulates BDNF cell biology, including Bdnf transcription, dendritic targeting and trafficking of BDNF mRNA and protein, and secretion and extracellular conversion of proBDNF to mature BDNF. Defects in these mechanisms contribute differentially to cognitive dysfunction and anxiety-like behaviors. Here we review recent studies, presented at a symposium at Neuroscience 2009, that describe regulatory mechanisms that permit rapid and dynamic refinement of BDNF actions in neurons.
Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience
View Paper: https://www.semanticscholar.org/paper/71ef39560619ef18baf439a9660b31879794b0e0
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In Cellular and Molecular Neuroscience
In Developmental Neuroscience
Citations in the corpus
- Adolescence as a neurobiological critical period for the development of higher-order cognition (2018, unknown): “Brain derived neurotrophic factor (BDNF) expression is activitydependent and facilitates plastic changes to neuronal form, including dendritic growth and synaptogenesis (Greenberg et al., 2009).”
- Microglia promote learning-dependent synapse formation through BDNF (2013, result): “Our results showing that the overall levels of BDNF protein do not change in the absence of microglial BDNF are in agreement with previous findings that small changes in BDNF levels or the presence of a SNP in the BDNF gene could have significant neurological effects (Greenberg et al., 2009).”
- Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway (2013, background): “BDNF promotes many aspects of brain development, including neuronal cell survival, differentiation, migration, dendritic arborization, synaptogenesis, and plasticity (Greenberg et al., 2009; Park and Poo, 2013).”