Brain-Derived Neurotrophic Factor val66met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance

By Ahmad R. Hariri, Terry E. Goldberg, Venkata S. Mattay, Bhaskar S. Kolachana, J. Callicott, Michael Egan, Daniel R. Weinberger. Journal of Neuroscience, 2003

1,079 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/1bc093c7e978b2506130513a48c9d4c51f7d44b9

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Citations in the corpus

Neurotrophin-regulated signalling pathways (2006, background): “The presence of a single nucleotide polymorphism in the BDNF gene resulting in a V66M mutation in the BDNF prohormone domain leads to selective impairments in hippocampal episodic memory and abnormal hippocampal function (Egan et al. 2003; Hariri et al. 2003).”
ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTR and Sortilin (2005, background): “…et al., 1997; Cosgaya et al., 2002; Carter et al., 2003), BDNF exhibits survival and synaptic actions in adulthood with distinct behavioral effects on memory, food intake and energy balance, and mood (Lyons et al., 1999; Kernie et al., 2000; Hariri et al., 2003; Xu et al., 2003; Pang et al., 2004).”
Event-Related Potentials, Emotion, and Emotion Regulation: An Integrative Review (2010, background): “Other research has documented similar patterns of neural activity when examining how attentional focus and evaluation at encoding influence emotional processing, such as categorizing unpleasant stimuli on non-affective versus affective dimensions (Hariri et al., 2003; Keightley et al., 2003; Mathews”
The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology (2004, positive): “A common polymorphism in the BDNF gene (val66met) in the 5Ј signal domain has been shown to affect intracellular packaging and regulated secretion of BDNF (Egan et al., 2003; Chen et al., 2004) and also human hippocampal function and episodic memory (Egan et al., 2003; Hariri et al., 2003).”
Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons (2004, background): “The major phenotype observed in humans, memory impairment, has been shown to be present in these subjects heterozygous for the Met polymorphism (Egan et al., 2003; Hariri et al., 2003).”
Potential therapeutic uses of BDNF in neurological and psychiatric disorders (2011, background): “The Val/Met variant is associated with impaired episodic memory and other measures of human cognition, along with reduced hippocampal activation as measured by functional magnetic resonance imaging (MRI”
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway (2013, background): “Highlighting the relevance of BDNF in human, individuals carrying the Val66Met mutation in the BDNF gene exhibit decreased secretion of BDNF, and display a decreased volume of specific brain regions, deficits in episodic memory function, and increased anxiety and depression (Egan et al., 2003; Harir”
The yin and yang of neurotrophin action (2005, background): “Humans with the Met allele have a selective impairment in hippocampus-dependent episodic memory, lower levels of hippocampal N -acetylaspartate (NAA, a putative measure of neuronal integrity and synaptic abundance) and abnormal hippocampal function (as recorded by functional MRI”