Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation.

By Zhaolan Zhou, Elizabeth J. Hong, Sonia Cohen, Wen-Ning Zhao, H. H. Ho, L. Schmidt, Wen G. Chen, Yingxi Lin, Erin M. Savner, Eric C. Griffith and 4 more. Neuron, 2006

907 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/58365d563faad018afef679e8212ac0faf3e7d7e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Hongjun Song
2. Guo-li Ming
3. Mark F. Bear
4. H. Zoghbi
5. Fred H. Gage
6. J. Sweatt
7. Yangling Mu
8. E. Nestler

In Genetics

1. Hongjun Song
2. Guo-li Ming
3. H. Zoghbi
4. Mark F. Bear
5. E. Nestler
6. Fred H. Gage
7. Thuc M. Le
8. G. Fan

In Molecular Biology

1. E. Nestler
2. Fred H. Gage
3. Hongjun Song
4. Guo-li Ming
5. H. Zoghbi
6. G. Fan
7. A. Bird
8. Mark F. Bear

Citations in the corpus

• Epigenetic regulation of neurogenesis in the adult mammalian brain (2011, background): “neuronal activity-induced calcium influx triggers phosphorylation of MeCP2 at serine 421 to facilitate its release from the promoter and subsequent transcription of BDNF (Chen et al., 2003; Zhou et al., 2006).”
• A model for neural development and treatment of Rett Syndrome using human induced pluripotent stem cells (2010, background): “CamK activation has been reported to induce phosphorylation of MeCP2, which was further postulated to regulate neuronal spine maturation (Tao et al., 2009; Zhou et al., 2006).”
• Epigenetic regulation in psychiatric disorders (2007, background): “Bdnf is a presumed target of MeCP2 transcriptional repression and is likely to be one of many such targets that are involved in Rett syndrom”
• Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. (2012, background): “This notion is supported by the finding that activity leads to phosphorylation of MeCP2 at S421 (Chen et al. 2003; Martinowich et al. 2003; Zhou et al. 2006).”
• The Angelman Syndrome-associated ubiquitin ligase Ube3A regulates synapse development by ubiquitinating Arc (2010, neutral): “…Ube3A knockout brains, suggesting that the increase in Arc in Ube3A knockout mouse brain is not the 708 Cell 140, 704–716, March 5, 2010 ª2010 Elsevier Inc. result of an overall increase in the activity-dependent gene response (Figure 3F and data not shown) (Zhou et al., 2006; Lin et al., 2008).”
• DNA Methylation and Its Basic Function (2013, background): “MBDs like MeCP2 undergo posttranslational modifications that alter their ability to bind to DNA (Zhou et al, 2006; Tao et al, 2009).”
• Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state (2010, background): “MeCP2 undergoes site-specific phosphorylation following synaptic firing, which is reported to alter its affinity for DNA and its nuclear distribution (Chen et al., 2003; Zhou et al., 2006).”
• EPIGENETIC REGULATION OF BDNF GENE TRANSCRIPTION IN THE CONSOLIDATION OF FEAR MEMORY (2008, background): “Thus, one appealing but very speculative hypothesis at this point is that NMDA receptor-mediated signaling may target MeCP2 to specific bdnf gene promoter or exonic regions to regulate bdnf gene methylation states during associative memory formation (Chen et al., 2003; Zhou et al., 2006).”
• BDNF — a key transducer of antidepressant effects (2015, background): “Activity-dependent BDNF transcription can also be regulated by epigenetic changes of the chromatin structure, adding yet another level of regulation (Kumar et al., 2005; Zhou et al., 2006).”
• The story of Rett syndrome: from clinic to neurobiology. (2007, neutral): “Neuron 56 , November 8, 2007 ª 2007 Elsevier Inc. 429 thus allowing transcription (Chen et al., 2003; Zhou et al., 2006) (Figure 3A).”