White Fat Progenitors Reside in the Adipose Vasculature

By Wei Tang, Daniel Zeve, J. M. Suh, D. Bosnakovski, M. Kyba, R. Hammer, M. Tallquist, J. Graff. Science, 2008

1,065 citations recorded by the source corpus.

White adipose (fat) tissues regulate metabolism, reproduction, and life span. Adipocytes form throughout life, with the most marked expansion of the lineage occurring during the postnatal period. Adipocytes develop in coordination with the vasculature, but the identity and location of white adipocyte progenitor cells in vivo are unknown. We used genetically marked mice to isolate proliferating and renewing adipogenic progenitors. We found that most adipocytes descend from a pool of these proliferating progenitors that are already committed, either prenatally or early in postnatal life. These progenitors reside in the mural cell compartment of the adipose vasculature, but not in the vasculature of other tissues. Thus, the adipose vasculature appears to function as a progenitor niche and may provide signals for adipocyte development.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/8befb6cd9740136c967970b6bf9509aae4dc92f5

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Citations in the corpus

Molecular mechanisms of cancer development in obesity (2011, background): “Given the close relationship between the vasculature and adipose tissu”
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017, positive): “Tang et al. demonstrated that these mural cells with high adipogenic potential can be identified by expression of PDGFR-β (20).”
Mechanisms and Metabolic Implications of Regional Differences among Fat Depots (2013, background): “Preadipocytes tend to be associated with blood vessels and may be derived from fat-tissue endothelial cells or pericytes (Gupta et al., 2012; Tang et al., 2008; Tran et al., 2012).”
Forming functional fat: a growing understanding of adipocyte differentiation (2011, background): “In vivo development of fat WAT compartments begin to develop in late gestatio”
Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration (2017, methodology): “…1, 2017 RESULTS Identification of the Bone Adipocytic Lineage To delineate the heterogeneous composition of the mesenchymal lineage of the bone, we used flow cytometry as reported in adipose tissues and bone (Morikawa et al., 2009a; Rodeheffer et al., 2008; Schulz et al., 2011; Tang et al., 2008).”
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis (2010, background): “Adipogenic progenitors expressing identical surface markers were recently isolated from white adipose depot”
Adipose tissue plasticity in health and disease (2022, background): “Taken together, these results suggest that Pdgfra+ ( ± Pdgfrb ) adventitial ﬁbroblasts, rather than mural cells, are the primary source of new adipocytes in WAT (Figure 5).”
Adipose Tissue Heterogeneity: Implication of depot differences in adipose tissue for Obesity Complications (2012, background): “Unlike white adipocytes which have mesenchymal or pericyte origins (Tang et al. 2008), brown adipocytes are derived either from myogenic lineage or transdifferentiation from white adipocytes (“brite”) (Kajimura et al. 2010).”
Identification of white adipocyte progenitor cells in vivo. (2008, background): “Cell 135, 240–249, October 17, 2008 ª2008 Elsevier Inc. 245 been confirmed in vivo with PPARg-reporter mice (Tang et al., 2008).”