Molecular mechanisms of cancer development in obesity
By M. Khandekar, P. Cohen, B. Spiegelman. Nature Reviews. Cancer, 2011
865 citations recorded by the source corpus.
Subfields: Cancer Research, Epidemiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/bcd38864e9da075f76a18e0c5a7cbfb3170d29b5
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
In Epidemiology
In Molecular Biology
- B. Spiegelman
- E. Rosen
- G. De Pergola
- F. Silvestris
- G. Hotamışlıgil
- Y. Sautin
- Richard J. Johnson
- Christoph Handschin
Citations in the corpus
- Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity (2013, background): “The p(corr)[1] values represent the interclass difference and p[1] values represent the relative abundance of the ions.”
- In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high fat feeding (2012, neutral): “Growing evidence indicates that disruption of the interrelated metabolic, endocrine, and immune functions of adipose tissue, as occurs during overnutrition, contributes to risk of diabetes, cardiovascular disease, and certain cancers (Khandekar et al., 2011).”
- Accessories to the crime: functions of cells recruited to the tumor microenvironment. (2012, neutral): “…by CAFs will prove to be operative in many forms of human cancer, and may also have differential clinical implications for individual patients with the same tumor type, such as obese patients whose cancers have been associated with more aggressive characteristics (Khandekar et al., 2011).”
- Obesity as a Major Risk Factor for Cancer (2013, background): “) that infiltrate adipose tissues in obese patients [69].”
- What We Talk About When We Talk About Fat (2014, positive): “Several mechanisms have been proposed for this association, including the antiapoptotic effects of obesity-associated hyperinsulinemia, enhanced aromatization of sex steroids (particularly relevant for breast and endometrial cancer) in adipose tissue, and the elaboration of paracrine and endocrine f”