Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

By A. Joe, L. Yi, Anuradha Natarajan, F. Le Grand, L. So, Joyce Wang, Michael A. Rudnicki, F. Rossi. Nature Cell Biology, 2010

1,550 citations recorded by the source corpus.

Efficient tissue regeneration is dependent on the coordinated responses of multiple cell types. Here, we describe a new subpopulation of fibro/adipogenic progenitors (FAPs) resident in muscle tissue but arising from a distinct developmental lineage. Transplantation of purified FAPs results in the generation of ectopic white fat when delivered subcutaneously or intramuscularly in a model of fatty infiltration, but not in healthy muscle, suggesting that the environment controls their engraftment. These cells are quiescent in intact muscle but proliferate efficiently in response to damage. FAPs do not generate myofibres, but enhance the rate of differentiation of primary myogenic progenitors in co-cultivation experiments. In summary, FAPs expand upon damage to provide a transient source of pro-differentiation signals for proliferating myogenic progenitors.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bc9bb4900e06e943eb4fc20c06bf5c8f728ee1e1

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Citations in the corpus

What We Talk About When We Talk About Fat (2014, neutral): “These cells can be distinguished from myogenic satellite cells by the expression of PDGFRa, and they arise from a different developmental lineage than the surrounding muscle (Joe et al., 2010; Uezumi et al., 2010).”
In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high fat feeding (2012, positive): “Several groups have isolated distinct cell populations from adipose tissues and muscle that have the potential to form white or brown adipocytes in vitro and in vivo, following transplantation (Joe et al., 2010; Petrovic et al., 2010; Rodeheffer et al., 2008; Schulz et al., 2011; Uezumi et al., 2010”
Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration (2011, background): “Furthermore, cellcell interactions play an important role in forming this tissue as multipotent fibroblastic/adipogenic mesenchymal progenitors (FAPs) interact with satellite cells to regulate muscle homeostasis (Joe et al., 2010; Uezumi et al., 2010), and endothelial cells were reported to affect s”
Adaptive thermogenesis in adipocytes: is beige the new brown? (2013, background): “Subpopulations of adipose progenitors have been isolated using different combinations of cell surface markers from enzyme-digested adipose tissue and skeletal muscle (Rodeheffer et al. 2008; Joe et al. 2010; Uezumi et al. 2010).”
Satellite cells and the muscle stem cell niche. (2013, background): “Notably, muscle SP cells (Sca-1 /ABCG2 ) are also CD34 and thus could be originating from the same lineage as FAPs and PICs (226).”
Beige Adipocytes are a Distinct Type of Thermogenic Fat Cell in Mouse and Human (2012, background): “See also Figure S2. presence of various environmental cues (Joe et al., 2009, 2010; Lee et al., 2012; Rodeheffer et al., 2008; Schulz et al., 2011; Uezumi et al., 2010).”
Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle (2011, background): “PDGFRa+ cells in skeletal muscle also coexpressed Sca-1 (Joe et al., 2010; Uezumi et al., 2010).”
Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling (2011, background): “In addition, adipocyte precursor cells have also been found within skeletal muscle and may signal to muscle precursor cells to promote muscle differentiation (Joe et al., 2010; Uezumi et al., 2010).”
Fibroblasts: origins, definitions, and functions in health and disease (2021, background): “Similar to skin and heart muscle, which we discuss below, skeletal muscle fibroblasts with progenitor properties express Sca1 (Joe et al., 2010; Uezumi et al., 2010) and, similar to lungs and heart, Gli1 (Kramann et al.”
Aberrant repair and fibrosis development in skeletal muscle (2011, background): “Whether FAP conversion also occurs during aging, and whether Basal lamina ECM deposition Satellite cell Fibro/adipogenic progenitor Resident macrophage Fibroblast Increased number of fibroblasts Fibrogenic-converted myogenic cells Myofiber Atrophic myofiber Young Old Figure 5 Myofiber growth and ext”