An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

By C. Opitz, Ulrike Litzenburger, F. Sahm, Martina Ott, Isabel Tritschler, S. Trump, T. Schumacher, L. Jestaedt, D. Schrenk, Michael Weller and 9 more. Nature, 2011

1,776 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Health, Toxicology and Mutagenesis, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8be16c087ede860f3dc75e6fea811daa15feafd2

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In Biological Psychiatry

In Health, Toxicology and Mutagenesis

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Citations in the corpus

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism (2018, background): “However, the effects of dietary Trp are mediated by its metabolites, which act as AhR ligands, and not by Trp itself (Opitz et al., 2011).”
Regulation of the immune response by the aryl hydrocarbon receptor (2018, background): “Kyn, for example, is produced by glioma cells (Opitz et al., 2011) and has been described to boost the differentiation of Treg cells (Mezrich et al., 2010).”
Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health (2017, background): “The expression of IDO and KATs allow Trp to be metabolized to Kyna, a GPR35 agonist (13) and a ligand for the transcription factor aryl hydrocarbon receptor (AhR) (similar activity has been shown for Kyn) (14, 15).”
T cell metabolism drives immunity (2015, background): “The metabolic byproduct of tryptophan catabolism, kynurenine, can ligate the aryl hydrocarbon receptor and enhance polarization of CD4 T cells to a T reg phenotype (Mezrich et al., 2010; Opitz et al., 2011).”
The Metabolic Signature of Macrophage Responses (2019, background): “From a mechanistic point of view, while tryptophan depletion inhibits rapid expansion of activated T cells, tryptophan-derived catabolites act as ligands of the aryl hydrocarbon receptors (AHR) (140).”
Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. (2013, positive): “In particular, L-kynurenine, the first breakdown product in the IDO1-dependent Trp degradation pathway, activates the aryl hydrocarbon receptor (AhR) in lymphoid tissues (Opitz et al., 2011) and promotes Treg cell development (Fallarino et al.”
Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. (2012, methodology): “suppression of constitutive AHR activity, lending support to the hypothesis that endogenous kynurenine drives AHR activity in cancer cells (10).”
Kynurenine pathway metabolism and the microbiota‐gut‐brain axis (2017, background): “Although kynurenine has been regarded as an inert precursor to downstream neuroactive agents, it also activates the aryl hydrocarbon receptor (Julliard et al., 2014; Kawasaki et al., 2014; Nuti et al., 2014; Opitz et al., 2011).”
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and CNS inflammation via the aryl hydrocarbon receptor (2016, neutral): “EAE was induced in eight to ten weeks old mice by subcutaneous immunization with 200 μg MOG 35–55 peptide emulsified in complete Freund’s adjuvant (CFA, Difco Laboratories) per mouse, followed by administration of 200 ng pertussis toxin (PTX, List biological laboratories, Inc.) on days 0 and 2 as de”