T cell metabolism drives immunity

By Michael D. Buck, David O’Sullivan, Erika L. Pearce. Journal of Experimental Medicine, 2015

1,109 citations recorded by the source corpus.

Buck et al. discuss the role of lymphocyte metabolism on immune cell development and function.

View Paper: https://www.semanticscholar.org/paper/0711357129fee45a70b2c9484097b68d0d5047db

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In Immunology

Citations in the corpus

Bioenergetic insufficiencies due to metabolic alterations regulated by PD-1 are an early driver of CD8+ T cell exhaustion (2016, background): “Teff cells generated during acute infections switch to anabolic metabolism dominated by aerobic glycolysis (Buck et al., 2015).”
Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism (2018, background): “The effector phase is finally marked by a concomitant high glycolytic rate and OXPHOS activity (Buck et al., 2015; O’Sullivan and Pearce, 2015), something we see after short-term activation of CD8+ T cells from HFD-fed animals, indicating that dietary fiber promotes immediate effector cell…”
Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity (2020, background): “Activated T cells are highly proliferative and rely on specific metabolic pathways to sustain T cell effector functions (Buck et al., 2015).”
Immunometabolism governs dendritic cell and macrophage function (2016, result): “This is similar to the situation in T cells, where glycolysis is needed for Th17 function (the inflammatory lymphocyte), but if this is blocked, then the T cell becomes a regulatory T cell, which is antiinflammatory (Buck et al., 2015).”
Metabolic Instruction of Immunity (2017, positive): “On the one hand, the engagement of aerobic glycolysis by activated T cells generates by-products of intermediary metabolism that supply substrates used to build biomass and fuel proliferation, provides an avenue for cells to support the equilibrium of reducing and oxidizing equivalents used to relea”