Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health

By Igor Červenka, Leandro Z. Agudelo, J. Ruas. Science, 2017

1,193 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/2107a96aaaf548cdfb99ff7f8a12a2166815d45b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. C. Nemeroff
2. Eléonore Beurel
3. M. Toups

In Biological Psychiatry

1. C. Nemeroff
2. Eléonore Beurel
3. M. Toups

Citations in the corpus

• Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease. (2018, neutral): “Kynurenine pathway Trp metabolism through the KP in the gut is mediated by the rate-limiting enzyme IDO1 and leads to the production of kynurenine (Kyn) and downstream products such as quinolinic acid (QA), niacin, nicotinamide adenine dinucleotide (NAD) and kynurenic acid (Kna) (Cervenka et al., 20”
• Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain. (2019, background): “Since circulating indole derivatives, such as IAA and IPA, can cross the BBB, the mediatory role of indolic metabolites in the context of the GBA is of special interest.”
• The Bidirectional Relationship of Depression and Inflammation: Double Trouble (2020, background): “When tryptophan is catabolized, intermediates collectively known as kynurenines are produced (Cervenka et al., 2017).”