Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion.

By M. Plattén, Wolfgang Wick, B. J. Van den Eynde. Cancer Research, 2012

643 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0f6c9339e43a9b92bc92705a63a4f146fb87e642

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In Molecular Biology

1. Alec C. Kimmelman
2. C. Lyssiotis

Citations in the corpus

• T Cell Dysfunction in Cancer (2018, background): “Second, tryptophan is lacking in some TMEs due to the secretion of the tryptophan metabolizing enzyme IDO by tumor cells and suppressive immune cells, also leading to an increase in its immunosuppressive catabolite kynurenine (Platten et al., 2012).”
• Metabolic Interactions in the Tumor Microenvironment (2017, background): “For these reasons, selective inhibitors of the first step in tryptophan metabolism are being tested in clinical trials to boost tumor immune responses [84].”