Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi

By Scott M. Hammond, S. Boettcher, Amy A. Caudy, R. Kobayashi, Gregory J. Hannon. Science, 2001

1,637 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/8b5c636284f1ab3f8b05d4754c16a3f06a3b8c08

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Citations in the corpus

Mili, a mammalian member of piwi family gene, is essential for spermatogenesis (2004, background): “Furthermore, in Drosophila, AGO1 and AGO2 are involved in RNAi, andpiwi is required for PTGS and for TGS, which is induced by multiple copies of Alcohol dehydrogenase (Hammond et al., 2001; Pal-Bhadra et al., 2002; Williams and Rubin, 2002).”
A biochemical framework for RNA silencing in plants. (2003, background): “…2001; Tijsterman et al. 2002) and the requirement for one or more members of the Argonaute family of proteins (Tabara et al. 1999; Fagard et al. 2000; Hammond et al. 2001; Hutvágner and Zamore 2002; Kennerdell et al. 2002; Martinez et al. 2002a; Pal-Bhadra et al. 2002; Williams and Rubin 2002).”
Involvement of microRNA in AU-rich element-mediated mRNA instability. (2005, background): “The RISC complex in Drosophila cells contains argonaute 2, the vasa intronic gene product (VIG), the Drosophila homolog of the fragile X mental retardation protein dFXR, and the tudor staphylococcal nuclease (Tudor-SN) (Hammond et al., 2001; Caudy et al., 2003).”
Unlocking the potential of the human genome with RNA interference (2004, background): “However, evidence of an RNAi pathway in mammals came from the observation that key biochemical components of the RNAi pathway are conserve”
Mechanisms of gene silencing by double-stranded RNA (2004, background): “Every RISC or miRNP contains a member of the Argonaute (Ago) protein family; the Ago protein probably binds directly to the RNA in these complexes, although formal evidence for this is lackin”
Human MicroRNA Targets (2004, background): “Every RISC contains a member of the Argonaute protein family, which tightly binds the RNA in the complex (Hammond et al. 2001; Hutvá gner and Zamore 2002a; Martinez et al. 2002; Mourelatos et al. 2002).”
Molecular mechanisms of translational control (2004, background): “Although the exact composition of RISC and the miRNAcontaining ribonucleoprotein particles (miRNPs) is unknown, both contain proteins of the Argonaute family 56, 65 .”
RNA Interference: Biology, Mechanism, and Applications (2003, methodology): “In another report, the multicomponent RNAi nuclease was purified to homogeneity as a ribonucleoprotein complex of 500 kDa (97).”
Fertile Hypomorphic ARGONAUTE (ago1) Mutants Impaired in Post-Transcriptional Gene Silencing and Virus Resistance (2002, background): “Conversely, an additional member of this PAZ/ PIWI family, DmAGO2, was identified as part of the RISC complex in D. melanogaster (Hammond et al., 2001).”