Involvement of microRNA in AU-rich element-mediated mRNA instability.

By Qing Jing, Shuang Huang, Sabine Guth, Tyler Zarubin, A. Motoyama, Jianming Chen, F. D. Di Padova, Sheng-Cai Lin, H. Gram, Jiahuai Han. Cell, 2005

917 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d4bcad656af452aea0ceaf836caa7682abe03590

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Citations in the corpus

The neuronal microRNA system (2006, background): “when they bind in a manner capable of inducing target destructio”
microPrimer: the biogenesis and function of microRNA (2005, background): “Another example is the proposal that miR-16 in Drosophila plays a role in AU-rich element (ARE)-mediated mRNA degradation (Jing et al., 2005).”
Argonaute proteins: key players in RNA silencing (2008, background): “Indeed, AU-rich element-binding motifs and proteins have already been demonstrated to interfere with miRNA-mediated gene regulatio”
MicroRNA regulation by RNA-binding proteins and its implications for cancer (2011, background): “However, it has been reported that TTP interaction with AGO2 instead of binding to AREs enables miR-16-mediated repression of TNF and COX2 in human cell”
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. (2006, background): “In addition, animal miRNAs can also induce significant degradation of mRNA targets despite imperfect mRNA– miRNA base-pairing (Bagga et al. 2005; Jing et al. 2005; 3Present addresses: Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02141, USA; Computer Science…”
Control of translation and mRNA degradation by miRNAs and siRNAs. (2006, background): “In the case of ARE-mediated degradation, experiments suggest the miRNA/RISC complex is not involved in exosome-mediated decay because RNAi inhibition of exosome function has no impact (Jing et al. 2005).”
Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells. (2009, background): “[52] proposed that miR-16 specifically interacts with AU-rich elements in mRNA 30-UTR via its central part rather than the seed and causes mRNA destabilization.”
The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. (2007, background): “The miR-16 miRNA may be required for ARE-mediated mRNA decay (Jing et al. 2005), so that inhibition of miRNA biogenesis might additionally induce HMGA2 mRNA through the inactivation of the ARE pathway.”
MicroRNA functions in animal development and human disease (2005, background): “MicroRNAs may also play a role in AUrich element-mediated mRNA degradation (Jing et al., 2005).”