Mili, a mammalian member of piwi family gene, is essential for spermatogenesis

By Satomi Kuramochi‐Miyagawa, Tohru Kimura, Takashi W. Ijiri, Taku Isobe, Noriko Asada, Yukiko Fujita, M. Ikawa, N. Iwai, M. Okabe, W. Deng and 3 more. Development, 2004

820 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/2bae6051ed90920fd035cd549bab7e7317be0dd8

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Citations in the corpus

Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. (2006, background): “Spermatogenesis in Mili-null mice is blocked completely at the early prophase of the first meiosis (Kuramochi-Miyagawa et al. 2004).”
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. (2007, background): “Thus far, MIWI and MILI have been characterized in some detail , with mice bearing targeted mutations in either Miwi (Deng and Lin, 2002) or Mili (Kuramochi-Miyagawa et al., 2004) being male sterile.”
Distinguishing protein-coding and noncoding genes in the human genome (2007, background): “…is consistent with observations that PIWIL2 binds a smaller size range of piRNAs, more akin to the piRNAs found in invertebrates, and that it is the only PIWI protein in mammals that is expressed in both the embryonic and adult gonad (Kuramochi-Miyagawa et al. 2001, 2004; Aravin et al. 2006).”
Small non-coding RNAs in animal development (2008, background): “In Miwi - and Mili -null mutants, spermatogenesis was arrested during meiosis, with defects appearing earlier in Mili mutants, consistent with its early expressio”
Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. (2006, background): “In the mouse, all three members of the Piwi/prg AGO family, Miwi (Deng and Lin, 2002), Mili (Kuramochi-Miyagawa et al., 2004), and Miwi2 (G.J. Hannon, personal communication) are required for male fertility.”
The mammalian ovary from genesis to revelation. (2009, background): “Moreover, MILI is the only Piwi family protein detected in oocytes (626), but Mili knockout females are fertile (622), implying that piRNAs are not the only factors that maintain stability of the oocyte genome.”
The role of RNA interference in heterochromatic silencing (2004, background): “Finally, two out of nine Ago homologues in mice have been knocked out, and both mutants show spermatogenesis defects and male sterilit”
Non-coding RNAs in human disease (2011, background): “Knockout mouse models for the proteins that are involved in piRNA biogenesis (MIWI1, MILI2 and MIWI23) revealed a profound reactivation of transposon activity, which is thought to be responsible for the observed sterility in this mouse owing to impaired spermatogenesi”
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. (2007, neutral): “, submitted), Mili (Kuramochi-Miyagawa et al., 2004), and Miwi (Deng and Lin, 2002), being required for male fertility.”
PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. (2008, background): “piRNAs in Worms, Flies, and Mammals Piwi AGOs bind small RNAs (piRNAs) with the following characteristics: a Dicer-independent biogenesis, a 50 end with a monophosphate and a strong bias for Uracil, and a 30 end that is modified and resistant to periodate degradation (reviewed in Klattenhoff and Th”