Fertile Hypomorphic ARGONAUTE (ago1) Mutants Impaired in Post-Transcriptional Gene Silencing and Virus Resistance

By J. Morel, C. Godon, P. Mourrain, C. Beclin, Stéphanie Boutet, F. Feuerbach, F. Proux, H. Vaucheret. The Plant Cell Online, 2002

658 citations recorded by the source corpus.

Subfields: Mechanical Engineering, Organic Chemistry, Polymers and Plastics

View Paper: https://www.semanticscholar.org/paper/0e4be878cb3e27dfb649fa5256a929ad25536270

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Citations in the corpus

• Post-transcriptional small RNA pathways in plants: mechanisms and regulations. (2006, background): “The production of virus-derived siRNAs was observed in response to virus infection (Hamilton and Baulcombe 1999), and plant mutants defective in PTGS were hypersusceptible to virus infection (Mourrain et al. 2000; Dalmay et al. 2001; Qu et al. 2005; Schwach et al. 2005).”
• The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development. (2004, background): “AGO1 is the founding member of the ARGONAUTE protein family, which comprises 10 members in Arabidopsis (Morel et al. 2002).”
• Origin, biogenesis, and activity of plant microRNAs. (2009, positive): “Presumably, the point mutation in ago1–27 (Morel et al., 2002) uncouples slicing activity (which remains intact) from translational repression by disrupting interactions between AGO1 and other proteins specifically required for translation repression (Figure 2A, left).”
• Temporal regulation of shoot development in Arabidopsis thaliana by miR156 and its target SPL3 (2006, background): “, 1996; Telfer and Poethig, 1998), or for posttranscriptional gene silencing (PTGS, also known as RNAi) (Morel et al., 2002; Peragine et al., 2004), have a precocious vegetative phenotype.”
• Roles of plant small RNAs in biotic stress responses. (2009, background): “Consistently, Arabidopsis plants with knockdown mutations in the miRNA effector AGO1 are hypersusceptible to RNA virus infections (49).”
• The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. (2002, background): “In contrast, ZWILLE was found not to participate in PTGS at all (Morel et al. 2002).”
• RNAi-mediated pathways in the nucleus (2005, background): “, and in the maintenance of chromatin modifications at some loc”
• MicroRNAS and their regulatory roles in plants. (2006, background): “and hst mutants all have pleiotropic developmental defects that overlap with those of hypomorphic dcl1 plants (20, 30, 80, 94, 129).”
• Plant microRNA: a small regulatory molecule with big impact. (2006, background): “There are 10 proteins in the Arabidopsis ARGONAUTE protein family (Morel et al., 2002).”
• Antiviral immunity directed by small RNAs. (2007, positive): “Second, ago1 hypomorphic mutants are more susceptible to viruses (Morel et al., 2002).”