Molecular mechanisms of translational control

By F. Gebauer, Matthias W. Hentze. Nature reviews. Molecular cell biology, 2004

1,090 citations recorded by the source corpus.

Translational control is widely used to regulate gene expression. This mode of regulation is especially relevant in situations where transcription is silent or when local control over protein accumulation is required. Although many examples of translational regulation have been described, only a few are beginning to be mechanistically understood. Instead of providing a comprehensive account of the examples that are known at present, we discuss instructive cases that serve as paradigms for different modes of translational control.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0c2aa71286f46b3529d2fc8c6802ccfdd43b8646

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Citations in the corpus

5′-UTR RNA G-quadruplexes: translation regulation and targeting (2012, background): “The translation of an mRNA into its protein product involves three major steps: initiation (assembly of a ribosome on the mRNA platform), elongation (protein synthesis) and termination (disassembly of the ribosome) (78).”
Advance Publication by J-STAGE Japanese Journal of Infectious Diseases Isolation of human coronaviruses OC43, HKU1, NL63, and 229E in Yamagata, Japan, using primary human airway epithelium cells cultured by employing an air-liquid interface culture (2020, neutral): “In the cap-independent translation mechanism, special structures, known as hairpins and pseudoknots [20], as well as sequences such as internal ribosome entry sites and upstream open reading frames [21] at the 3′ or 5′ UTR regions of the mRNA help initiating the translation of the target mRNA.”
Regulating gene expression through RNA nuclear retention. (2005, background): “Furthermore, translation can be tightly regulated at either a global level or the level of specific mRNAs (i.e, via miRNAs) (reviewed, Gebauer and Hentze, 2004; He and Hannon, 2004).”
Molecular mechanisms of mTOR-mediated translational control (2009, background): “The limiting step of protein synthesis is translation initiation, during which the small ribosome subunit is recruited to the 5′ end of mRNA and scans towards the start codon, where the complete ribosome is subsequently assembled to begin polypeptide formatio”
The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. (2008, background): “In some cases, synaptic activity and/or developmental transitions can alleviate translational repression (Gebauer and Hentze, 2004; Richter and Sonenberg, 2005); con-”
Wound healing essentials: Let there be oxygen (2009, background): “Whereas changes in transcription can take hours to achieve, translational regulation is rapid and reversible.(193) Preferential translation of select mRNA is another hallmark of response to hypoxia.”
Long Non-coding RNAs in the Cytoplasm (2016, background): “Some lncRNAs also get involved in such regulation at the translational level, which can either repress (as exemplified for lincRNA-p21 below) or promote (as exemplified for AS Uchl1 below) translation. lincRNA-p21 The human lincRNA-p21 is also known as tumor protein p53 pathway corepressor 1…”
Mechanisms of microRNA‐mediated gene regulation (2007, background): “Finally, there are numerous other well-documented examples of post-transcriptional gene regulation at both the level of mRNA stability and the level of translation (at initiation and subsequent steps) that do not involve miR-NAs (reviewed in Refs [ 63 ] and [64]).”
MYC as a regulator of ribosome biogenesis and protein synthesis (2010, background): “The translational machinery is composed of ribosome subunits, mRNA, transfer RNAs (tRNAs), and translation initiation and elongation factors (reviewed in Ref”
THE MECHANISM OF EUKARYOTIC TRANSLATION INITIATION AND PRINCIPLES OF ITS REGULATION (2010, background): “Regulation by protein–RNA interactions in the 5′ UTR is surprisingly rare and there is just one well-studied example — ferritin mRNA”