Mechanisms of gene silencing by double-stranded RNA

By Gunter Meister, Thomas Tuschl. Nature, 2004

2,584 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/aed551025c8d064d5e8aaed56977aa17365d0333

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Citations in the corpus

The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2 (2011, background): “dtd" [ ]> MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene silencing by annealing to inexactly complementary sequences in the 3′-untranslated regions of target mRNA”
Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution (2009, positive): “quence (Cullen 2004; Meister and Tuschl 2004); (ii) the siRNA is loaded onto an enzyme complex that targets chromatin regions with DNA that is homologous to the siRNA, and alters chromatin into a silent state (Matzke and Birchler 2005; Ekwall 2007; Huettel et al.”
MicroRNA biogenesis and cancer. (2005, background): “For the few miRNAs whose function has been uncovered, they are important regulators of various aspects of developmental control in both plants and animals (1, 2 ). In the few years since the inception of this regulatory RNA phenomenon, much progress has been made towards an understanding of the mec”
RNA meets chromatin. (2005, background): “It has been recognized for some time that the “canonical” RNAi pathway uses small interfering RNAs (siRNAs) to induce degradation of cognate messenger RNAs in a sequence-specific manner (for review, see Hannon 2002; Meister and Tuschl 2004).”
Endogenous siRNAs Derived from a Pair of Natural cis-Antisense Transcripts Regulate Salt Tolerance in Arabidopsis (2005, neutral): “Phased Processing of nat-siRNAs siRNAs are extremely diverse, and their biogenesis is especially complex in plants (Xie et al., 2004; Baulcombe, 2004; Meister and Tuschl, 2004).”
MicroRNAs in human cancer. (2013, background): “Systemic administration of antisense oligonucleotide therapeutics to miR-122, a liver-enriched miRNA, in mice and primates was shown to alter lipid metabolism and hepatitis C viral load, resulting in reduced liver damage [ 117, 195– 197, 200, 201 ] .”
The delivery of therapeutic oligonucleotides (2016, background): “Both endogenous miRNAs and chemically synthesized externally administered siRNAs utilize Argonaute-containing RISC complexes to regulate gene expression (24,25).”
Factors Influencing Begomovirus Evolution and Their Increasing Global Significance: Implications for Sustainable Control (2006, background): “The pathways and mechanisms of PTGS (also termed RNA silencing or RNA interference) in plants, and of their modulation by viruses have been reviewed recently ( Baulcombe, 2004 ; Meister and Tuschl, 2004 ; Moissiard and Voinnet, 2004 ).”
Gardening the genome: DNA methylation in Arabidopsis thaliana (2005, background): “Small RNAs involved in these processes are generated by the well-studied RNAi pathway, in which dsRNA is cleaved into 21–25 nucleotide small interfering RNAs (siRNAs) by the ribonuclease Dice”
Loss-of-function approaches in comparative physiology: is there a future for knockdown experiments in the era of genome editing? (2019, background): “administration or introduction of short hairpin RNA (shRNA) expression vectors (Hannon, 2002; Meister and Tuschl, 2004; Rao et al., 2009).”
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. (2005, positive): “RNA, triggering its destruction (Hammond et al., 2001, Okamura et al., 2004; Meister et al., 2004b; Rand et al., 2004; Liu et al., 2004; Song et al., 2004; Rivas et al., 2005).”