Unlocking the potential of the human genome with RNA interference

By Gregory J. Hannon, John J. Rossi. Nature, 2004

1,138 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/716f4ebf4f20eee114f47a28aba5896afca2bfc8

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In Molecular Biology

Citations in the corpus

Highly Specific Gene Silencing by Artificial MicroRNAs in Arabidopsis[W][OA] (2006, methodology): “They can either be synthesized in vitro or by transgenic expression of a double-stranded precursor that folds back on itself as a hairpin (Hannon and Rossi, 2004).”
Transcriptional regulation and transformation by Myc proteins (2005, background): “Most probably, the advent of genome-wide short interfering (si)RNA libraries will allow the systematic identification of important genes in different tumours, and will resolve this key question in Myc biolog”
Illuminating the silence: understanding the structure and function of small RNAs (2007, background): “This dsRNA-processing step creates RNAs with 2-nt overhangs at their 3′ ends and phosphate groups at their 5′ end”
Strategies for silencing human disease using RNA interference (2007, background): “Mechanistic insights followed rapidly during the ensuing years, and with them came the increasing hope that RNAi pathways could be harnessed for the therapeutic intervention of human disease”
MicroRNA biogenesis: coordinated cropping and dicing (2005, background): “In-depth knowledge on miRNA biogenesis will also be crucial to improve RNAi technolog”
Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery. (2005, methodology): “Since its description in Caenorhabditis elegans (1) and mammalian cells (2), use of small interfering RNA (siRNA) as a method of gene silencing has rapidly become a powerful tool in protein function delineation, gene discovery, and drug development (3).”
Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance (2005, background): “To exclude the possibility of 'off-target' effects contributing to these observation”
RNA interference in the clinic: challenges and future directions (2010, background): “Briefly, double-stranded RNA (dsRNA) is recognized by an RNase type III enzyme, Dicer, and cleaved into small fragments 21–23 base pairs in lengt”
Induction and suppression of RNA silencing: insights from viral infections (2005, neutral): “, now widely used as a powerful technology for gene knockdow”
Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene Discovery (2009, background): “Indeed, high-throughput RNA interference approaches [92,93] might be used to evaluate many or all of the candidate cancer genes simultaneously.”