Localization of phosphatidylinositol 3‐phosphate in yeast and mammalian cells

By D. Gillooly, Isabel C. Morrow, M. Lindsay, R. Gould, Nia J. Bryant, J. Gaullier, Robert G. Parton, Harald A. Stenmark. EMBO Journal, 2000

1,114 citations recorded by the source corpus.

Subfields: Cell Biology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/8977ac49fe003282e776915979be37ee766dd2b1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. N. Mizushima
2. I. Slaninová
3. Beth Levine
4. T. Johansen
5. D. Klionsky
6. Harald A. Stenmark
7. T. Yoshimori
8. Y. Ohsumi

In Physiology

1. Beth Levine
2. N. Mizushima
3. T. Johansen
4. Harald A. Stenmark
5. T. Lamark
6. H. McBride
7. K. Guan
8. T. Yoshimori

In Surgery

1. N. Mizushima
2. K. Guan
3. Ari Helenius
4. Jatta Huotari
5. Beth Levine
6. Joungmok Kim

Citations in the corpus

• Lysosomes: fusion and function (2007, background): “The lumenal membrane vesicles are enriched in either lysobisphosphatidic acid or phosphatidylinositol 3-phosphat”
• Membrane recognition by phospholipid-binding domains (2008, background): “However, even the cooperation of these modes of interaction does not seem to be sufficient for in vivo targeting of some FYVE domains to PtdIns3P-containing endosomal membrane”
• Using HHsearch to tackle proteins of unknown function: A pilot study with PH domains (2016, background): “for 6 of these PH-like domains (all except Tph3p) and Age1p, since dimers can reveal weak membrane targeting.(66,67) All constructs”
• Antimicrobial mechanisms of phagocytes and bacterial evasion strategies (2009, background): “Phagolysosomes can be differentiated from late phagosomes by their paucity of LBPA or PI(3)P-enriched internal membrane”
• Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “The mammalian class III PI3K also has a role in endocytic sorting, and the hVps34/p150 complex is recruited to Rab5 positive endosomes (254, 1100) where it produces PtdIns3P, which attracts proteins that contain FYVE domains and PX domains (509, 752, 1409, 1750).”
• The biogenesis of multivesicular endosomes (2004, background): “In addition, phosphatidylinositol-3-phosphate (PtdIns3P) was found to accumulate within ECV/MVB”
• Endosome maturation (2011, background): “Factors proposed to be involved in ESCRT-independent ILV biogenesis include the lipids BMP/LBPA and ceramide, both of which have been demonstrated to spontaneously induce formation of internal vesicles in liposomes in vitro in the absence of any proteins (Matsuo et al, 2004; Trajkovic et al, 2008).”
• The endocytic pathway: a mosaic of domains (2001, background): “Although PtdIns(3)P–FYVE interactions are sufficient for early endosomal targetin”
• The emerging mechanisms of isoform-specific PI3K signalling (2010, background): “Under basal, unstimulated conditions, cells contain a substantial pool of PtdIns3P, which is mainly localized in endosome”